MCP-1, CCR2 유전자 다형성을 이용한 한국인 알레르기 비염환자에서의 감수성에 대한 연구

이재훈; 박수엽; 윤성원; 김정중; 최태욱; 오경재; 오차근

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자료유형: 학술저널

저자정보: 이재훈 박수엽 윤성원 김정중 최태욱 오경재 오차근

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제47권 제2호

발행연도: 2004.1

수록면: 127 - 131 (5page)

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Background and Objectives：A biallelic A/G polymorphism in the Monocyte chemotactic protein (MCP) -1 at position -2518 has been found to affect the level of MCP-1 expression. To investigate if these polymorphisms in chemokine ligand and receptor genes are relevant for the development of allergic rhinitis, we investigated polymorphisms of MCP-1 and CC chemokine receptor 2 (CCR2) known as the receptor of MCP-1. Materials and Method：Blood samples for genetic analysis were obtained from 198 individuals with allergic rhinitis and from 278 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for MCP-1 -2518 A/G (A/G polymorphism in the MCP-1 at position -2518) and CCR2 V64I polymorphisms (replacement of valine by isoleucine in CCR2 64) was used for genotyping. Results：There were no differences in the frequencies of the genotypes in the controls and patients (p>0.05). The frequencies of the MCP-1 G and CCR2 A alleles were not statistically different between controls and allergic rhinitis patients (p>0.05). The odds ratios (95% confidence interval) of MCP-1 G/G and CCR2 A/A genotypes for allergic rhinitis were not statistically significant, whereas, alleles frequencies of MCP-1 -2518G and CCR2 A of controls were various according to the ethnic background. Conclusion：Our result suggests MCP-1 -2518 A/G and CCR2 V64I polymorphisms are not part of the factors contributing to genetical susceptibility in the development of allergic rhinitis in Koreans.

#알레르기 비염·한국인·유전자 다형성. #MCP-1· CCR2· Rhinitis #allergic #perennial· Korea· Polymorphism.

참고문헌 (18)

참고문헌 신청

/ 1990 / Investigation of the geneticregulation in allergic rhinitis 17 : 23 ~ 32

/ 1992 / Molecular basis of human hypertension:Role ofangiotensinogen 71 : 169 ~ 180

/ 1994 / RANTES: A novel mediator ofallergic inflammation? 24 : 899 ~ 904

/ 1996 / IncreasedMCP-1, RANTES, and MIP-1α in bronchoalveolar lavagefluid of allergic asthmatic patients. 153 : 1398 ~ 1404

/ 1997 / MIP-1alpha and MCP-1 differentiallyregulate acute and relapsing autoimmune encephalomyelitis as wellas Th1/Th2 lymphocyte differentiation 62 : 681 ~ 687

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소속기관 원광대학교 의과대학 이비인후과학교실

주요연구분야 의약학 > 의학 일반 의약학 > 임상의학 > 이비인후과학

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