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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 77 - 83 (7page)
이용수
초록· 키워드
오류제보하기
Background and ObjectivesZZIn general, aminoglycosides are known to cause ototoxicity through the glutamate induced nitric oxide production. The N-methyl-D-aspartate (NMDA) related glutamate receptors have a pivotal role in aminoglycoside induced ototoxicity. Memantine is known as a safe NMDA antagonist and is also used in some neurologic insults, such as the Alzheimer disease. In this study, we observed the effect of memantine on gentamicin induced vestibulotoxicity in an animal model.
Materials and MethodZZVestibulotoxicity was induced with intratympanic administration of gentamicin and memantine was injected intraperitoneally to a study group. Histomorphological studies for vestibule were performed via light and electron microscopy. Immunohistochemical studies were performed for iNOS, nitrotyrosine and apoptosis via TUNEL staining.
ResultsZZThe numbers of hair cells were decreased significantly in the gentamicin group than in the gentamicin-memantine group. Increased immunoreactivities for iNOS and nitrotyrosine were observed in the gentamicin group than in the memantine-pretreated gentamicin group. TUNEL positive cells were more frequently observed in the gentamicin group than in the memantinepretreated gentamicin group.
ConclusionZZThis result shows that memantine has a protection effect on gentamicin-induced vestibulotoxicity in an animal model. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:77-83
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Basile AS / 1996 / N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss / Nat Med 2 (12) : 1338 ~ 1343
Basile AS / 1999 / Dizocilpine attenuates streptomycin-induced vestibulotoxicity in rats / Neurosci Lett 265 (2) : 71 ~ 74
Chen HS / 1992 / Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity / J Neurosci 12
Chen Z / 2003 / Acute treatment of noise trauma with local caroverine application in the guinea pig / Acta Otolaryngol 123 (8) : 905 ~ 909
Duan M / 2000 / Complementary roles of neurotrophin 3 and a N-methyl-D-aspartate antagonist in the protection of noise and aminoglycoside-induced ototoxicity / Proc Natl Aca
Basile AS / 1999 / Dizocilpine attenuates streptomycin-induced vestibulotoxicity in rats / Neurosci Lett 265 (2) : 71 ~ 74
Chen HS / 1992 / Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity / J Neurosci 12
Chen Z / 2003 / Acute treatment of noise trauma with local caroverine application in the guinea pig / Acta Otolaryngol 123 (8) : 905 ~ 909
Duan M / 2000 / Complementary roles of neurotrophin 3 and a N-methyl-D-aspartate antagonist in the protection of noise and aminoglycoside-induced ototoxicity / Proc Natl Aca
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