갑상선 미세유두상암에서 중심경부림프절 전이의 관련인자와 양상

김용완; 왕수건; 이진춘; 이병주; 이진우; 김용기; 김인주; 손석만

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자료유형: 학술저널

저자정보: 김용완 왕수건 이진춘 이병주 이진우 김용기 김인주 손석만

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제3호

발행연도: 2009.1

수록면: 232 - 236 (5page)

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Background and Objectives：Despite the overall excellent prognosis for patients with thyroid papillary microcarcinoma (PMC), PMC is associated with central compartment lymph node metastasis. The aim of this study is to evaluate the effect of clinical and pathological factors affecting the central compartment lymph node metastasis in thyroid PMC. Subjects and Method：We undertook a retrospective study of 161 patients treated between January, 2003 and June, 2007 for papillary thyroid microcarcinoma by total thyroidectomy and central compartment neck dissection (n=161) with or without comprehensive lateral neck dissection. Following factors were included to analyze the relationship of tumor size and central compartment lymph node metastasis； sex, age, extracapsular extension, lymphovascular tumor emboli, multifocality, bilaterality, AMES risk group, lateral cervical lymph node involvement. Results：In 109 of 161 patients (67.7%), tumor size between 5-10 mm was significantly related with extracapsular extension (p=0.027) and also with the AMES high risk group (p=0.007). In 75 of 161 patients (46.6%), central compartment lymph node metastasis were found. By univariate analysis, tumor multifocality, bilaterality, and lateral lymph node involvement were related with central compartment lymph node metastasis. But on multivariate analysis, tumor bilaterality (p=0.008) and lateral lymph node involvement (p=0.018) were significantly related with central compartment lymph node metastasis. Conclusion：Prophylactic neck dissection of central compartment lymph nodes in PMC should be recommended as a routine procedure particularly for patients with tumor bilaterality and metastatic lymph nodes in the lateral neck.

#갑상선·미세유두상암·림프절 전이·중심경 부 청소술 #Thyroid·Papillary microcarcinoma·Lymphatic metastasis·Neck dissection

참고문헌 (17)

참고문헌 신청

Baudin E / 1998 / Microcarcinoma of the thyroid gland: The Gustave-Roussy institute experience / Cancer 83 (3) : 553 ~ 559

Cappelli C / 2007 / Aggressiveness and outcome of papillary thyroid carcinoma (PTC) versus microcarcinoma (PMC): A mono-institutional experience / J Surg Oncol 95 (7) : 555 ~

Chow SM / 2003 / Papillary microcarcinoma of the thyroid-prognostic significance of lymph node metastasis and multifocality / Cancer 98 (1) : 31 ~ 40

Cooper DS / 2006 / Management guidelines for patients with thyroid nodules and differentiated thyroid cancer / Thyroid 16 (2) : 109 ~ 142

Corapcioglu D / 2006 / Papillary thyroid microcarcinomas of the thyroid gland and immunohistochemical analysis of expression of p53 protein in papillary microcarcinomas / J T

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