신생 흰쥐 난형낭의 조직배양 모델군에서 이독성 유발 후저출력 레이저에 의한 전정유모세포 재생 증진 효과에 대한 연구

정용원; 안진철; 임은석; 김영생; 이상훈; 이민영; 이정구

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자료유형: 학술저널

저자정보: 정용원 안진철 임은석 김영생 이상훈 이민영 이정구

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제50권 제1호

발행연도: 2007.1

수록면: 25 - 30 (6page)

이용수

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연구주제

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연구배경

🔬

연구방법

🏆

연구결과

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Background and Objectives：In normal postnatal mamalian inner ear sensory epithelium, regeneration of hair cells is a very rare event, but there is hair cell regeneration with partial restoration of the vestibular sensory epithelium following ototoxiIn this study, the efects of low-level laser on hair cell regeneration folowing gentamicin exposure in postnatal organotypic culture of rat utricles were investigated. Materials and Method：A long term organotypic culture of 2 to 7 day old rat utricular maculae was established to study aminoglycoside-induced vestibular hair cell renewal. The utricles were exposed to 1 mM of gentamicin for 48 hr and allowed to recover in a culture medium only or in a medium with daily iradiation of low-level laser, whereas the marker, to identify live hair cells in cultured tissues. Results：Los of hair cells was nearly stopped from 2 days after exposure to gentamicin；a peak of regeneration was reached after 18 days and sustained for two weks in the medium with the irradiation of low-level laser. Conclusion：These results suggest that low-level laser promotes spontaneous hair cell regeneration following gen-tamicin damage in utricular explants. (Korean J Otolaryngol 2007 ;50 :25-30)

#저출력 레이저·FM 1-43·난형낭. #Low-level laser· FM 1-43· Utricle.

참고문헌 (19)

참고문헌 신청

/ 1928 / The development in vitro of the isolated otocyst of the emb-ryonic fowl

/ 1959 / The ultrastructural organization of sensory epithelium in the developing fowl embryo otocyst

/ 1964 / On the cytological features of the cultivated spiral ganglion cells

/ 1984 / Neurotropic interactions during in vitro development of the inner ear

/ 1990 / Neurotropic effect of developing otic vesicle on cochleovestibular neu-rons: Evidence for nerve growth factor involvement

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