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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 141 - 147 (7page)
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Purpose: microRNAs (miRNAs) are non-coding RNAs composed of 20 to 22 nucleotides that regulate development and differentiationin various organs by silencing specific RNAs and regulating gene expression. In the present study, we show that the microRNA(miR)-183 cluster is upregulated during hair cell regeneration and that its inhibition reduces hair cell regeneration followingneomycin-induced ototoxicity in zebrafish. Materials and Methods: miRNA expression patterns after neomycin exposure were analyzed using microarray chips. Quantitativepolymerase chain reaction was performed to validate miR-183 cluster expression patterns following neomycin exposure (500 μM for 2 h). After injection of an antisense morpholino (MO) to miR-183 (MO-183) immediately after fertilization, hair cell regenerationafter neomycin exposure in neuromast cells was evaluated by fluorescent staining (YO-PRO1). The MO-183 effect also was assessed in transgenic zebrafish larvae expressing green fluorescent protein (GFP) in inner ear hair cells. Results: Microarray analysis clearly showed that the miR-183 cluster (miR-96, miR-182, and miR-183) was upregulated after neomycintreatment. We also confirmed upregulated expression of the miR-183 cluster during hair cell regeneration after neomycin-induced ototoxicity. miR-183 inhibition using MO-183 reduced hair cell regeneration in both wild-type and GFP transgenic zebrafishlarvae. Conclusion: Our work demonstrates that the miR-183 cluster is essential for the regeneration of hair cells following ototoxic injuryin zebrafish larvae. Therefore, regulation of the miR-183 cluster can be a novel target for stimulation of hair cell regeneration.
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