신생 흰쥐 난형낭의 조직 배양 모델에서 저출력 레이저의  Gentamicin 이독성 예방과 치료 효과

김정범; 정재윤; 안진철; 이정구; 오양희

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자료유형: 학술저널

저자정보: 김정범 정재윤 안진철 이정구 오양희

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제1호

발행연도: 2009.1

수록면: 19 - 28 (10page)

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Background and Objectives：The purpose of this study was to investigate the effects of low level laser for the prevention and treatment of aminoglycoside-induced vestibular ototoxicity. Materials and Method：An organotypic culture of 2 to 4 days old rat utricular maculae was established. Rats were divided into 6 groups according to the treadtment of the utricles：G (gentamicintreated), L (laser-irradiated), LG (laser-irradiated and gentamicin-treated), GL (gentamicin-treated and laser-irradiated), LGL (gentamicin-treated during laser-irradiated) and C (control). After organotypic culture, the utricles of 6 groups were examined by confocal laser scanning electron microscope and scanning electron microscope. The results of each group were compared with each other by statistical methods. Results：The number of vestibular hair cells of the group G was smaller compared to that of the group C. The group L had no difference compared with the group C. The groups LG and GL showed more vestibular hair cells compared with the group G. The group LG showed more vestibular hair cells than the group GL. The group LGL showed most vestibular hair cells compared to that of the groups G, LG, and GL. Conclusion：The most effective treatment of aminoglycosideinduced vestibular otoxicity is the irradiation of low level laser before and after the insult of the aminoglycoside. Further clinical studies using low level laser were needed to prevent aminoglycoside-induced ototoxicity and to promote the regeneration of vestibular hair cells.

#겐타마이신·이독성·저출력 레이저 #Gentamicin·Ototoxicigty·Low level laser

참고문헌 (18)

참고문헌 신청

Anders JJ / 2004 / Phototherapy promotes regeneration and functional recovery of injured peripheral nerve / Neurol Res 26 (2) : 233 ~ 239

Assia E / 1989 / Temporal parameters of low-energy laser irradiation for optimal delay of posttraumatic degeneration of rat optic nerve / Brain Res 476 (2) : 205 ~ 212

Balak KJ / 1990 / Regenerated hair cells can originate from supporting cell progency: Evidence from phototoxicity and laser ablation experiments in the lateral line system /

Berggren D / 2003 / Spontaneous hair-cell renewal following gentamicin exposure in postnatal rat utricular explants / Hear Res 180 (1) : 114 ~ 125

Betz WJ / 1996 / Imaging exocytosis and endocytosis / Curr Opin Neurobiol 6 (3) : 365 ~ 371

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