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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 97 - 100 (4page)
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초록· 키워드
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Toxic epidermal necrolysis (TEN) is a rare, acute, serious, and potentially fatal skin disease, in which cell death causes the epidermis to separate from the dermis. It is thought to be a hypersensitivity complex that affects the skin and mucous mem branes, and is caused by certain medications, infections, genetic factors, underlying immunologic disease, or more rarely, cancers. We report two cases of TEN associ ated with deflazacort (DFZ), a derivative of prednisolone, used in the first episode of nephrotic syndrome (NS). The skin eruption appeared on the 4 th and 5 th weeks after DFZ administration, while NS was in remission. The widespread lesions were managed by intensive supportive treatment, discontinuation of DFZ, and oral administration of cyclosporine. Both patients showed a rapid improvement in symptoms of TEN without any complications or relapse of NS.
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참고문헌 (13)
참고문헌 신청
Ferrandiz-Pulido C / 2013 / A review of causes of Stevens-Johnson syndrome and toxic epidermal necrolysis in children / Arch Dis Child 98:998~1003
김동욱 / 2006 / Steroid and enalapril therapy-possible cause of toxic epidermal necrolysis / Korean Journal of Pediatrics 49(3):332~336
이은채 / 2014 / Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome / Kidney Research and Clinical Practice 33(4):222~225
Wood ML / 1985 / Deflazacort-a safer systemic steroid for the treatment of chronic dermatoses / Br J Dermatol 113(s 29):34~35
Harr T / 2010 / Toxic epidermal necrolysis and Stevens-Johnson syndrome / Orphanet J Rare Dis 5:39
김동욱 / 2006 / Steroid and enalapril therapy-possible cause of toxic epidermal necrolysis / Korean Journal of Pediatrics 49(3):332~336
이은채 / 2014 / Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome / Kidney Research and Clinical Practice 33(4):222~225
Wood ML / 1985 / Deflazacort-a safer systemic steroid for the treatment of chronic dermatoses / Br J Dermatol 113(s 29):34~35
Harr T / 2010 / Toxic epidermal necrolysis and Stevens-Johnson syndrome / Orphanet J Rare Dis 5:39
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