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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 286 - 291 (6page)
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Tenofovir disoproxil fumarate (TDF) is effective against chronic hepatitis B (CHB) infection and its use is increasing rapidly worldwide. However, it has been established that TDF is associated with renal toxicity in human immunodeficiency virus-infected patients, while severe or symptomatic TDF-associated nephrotoxicity has rarely been reported in patients with CHB. Here we present two patients with TDF-associated nephrotoxicity who were being treated for CHB infection. The first patient was found to have clinical manifestations of proximal renal tubular dysfunction and histopathologic evidence of acute tubular necrosis at 5 months after starting TDF treatment. The second patient developed acute kidney injury at 17 days after commencing TDF, and he was found to have membranoproliferative glomerulonephritis with acute tubular injury. The renal function improved in both patients after discontinuing TDF. We discuss the risk factors for TDF-associated renal toxicity and present recommendations for monitoring renal function during TDF therapy.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Gallant JE / 2003 / Tenofovir disoproxil fumarate / Clin Infect Dis 37:944~950
Kearny BP / 2004 / Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics / Clin Pharmacokinet 43:595~612
Yuen MF / 2011 / Treatment of chronic hepatitis B: evolution over two decades / J Gastroenterol Hepatol 26(Suppl 1):138~143
Van Rompay KK / 2008 / Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effects / Antimicrob Agents Chemother 52:3144~3160
Verhelst D / 2002 / Fanconi syndrome and renal failure induced by tenofovir: a first case report / Am J Kidney Dis 40:1331~1333
Kearny BP / 2004 / Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics / Clin Pharmacokinet 43:595~612
Yuen MF / 2011 / Treatment of chronic hepatitis B: evolution over two decades / J Gastroenterol Hepatol 26(Suppl 1):138~143
Van Rompay KK / 2008 / Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effects / Antimicrob Agents Chemother 52:3144~3160
Verhelst D / 2002 / Fanconi syndrome and renal failure induced by tenofovir: a first case report / Am J Kidney Dis 40:1331~1333
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