지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 152 - 159 (8page)
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초록· 키워드
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Background/Aims: Tenofovir disoproxil fumarate (TDF) exhibits similar antiviral efficacy against treatment-naïve and lamivudine (LAM)-resistant chronic hepatitis B (CHB). However, there are few clinical reports on the antiviral effects of TDF–LAM combination therapy compared to TDF monotherapy in patients with LAM-resistant CHB.
Methods: We investigated the antiviral efficacy of TDF monotherapy vs. TDF–LAM combination therapy in 103 patients with LAM-resistant CHB.
Results: The study subjects were treated with TDF alone (n=40) or TDF–LAM combination therapy (n=63) for ≥6 months. The patients had previously been treated with TDF-based rescue therapy for a median of 30.0 months (range, 8–36 months). A virologic response (VR) was achieved in 99 patients (96.1%): 95.0% (38/40) of patients in the TDF monotherapy group and 96.8% (61/63) of patients in the TDF–LAM combination therapy group. The VR rates were not significantly different between the TDF monotherapy and TDF–LAM combination therapy groups (88.9 vs. 87.3% at month 12, and 94.4 vs. 93.7% at month 24, log-rank P=0.652). Univariate and multivariate analyses revealed that none of the pretreatment factors were significantly associated with VR.
Conclusions: TDF monotherapy was as effective as TDF–LAM combination therapy for maintaining viral suppression in the vast majority of patients with LAM-resistant CHB, which suggests that TDF add-on therapy with LAM is unnecessary
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참고문헌 (34)
참고문헌 신청
Evans AA / 2013 / Chronic HBV infection outside treatment guidelines: is treatment needed? / Antivir Ther 18:229~235
Chen CJ / 2006 / Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level / JAMA 295:65~73
Iloeje UH / 2006 / Predicting cirrhosis risk based on the level of circulating hepatitis B viral load / Gastroenterology 130:678~686
Hosaka T / 2013 / Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection / Hepatology 58:98~107
Lai CL / 2013 / Prevention of hepatitis B virus-related hepatocellular carcinoma with antiviral therapy / Hepatology 57:399~408
Chen CJ / 2006 / Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level / JAMA 295:65~73
Iloeje UH / 2006 / Predicting cirrhosis risk based on the level of circulating hepatitis B viral load / Gastroenterology 130:678~686
Hosaka T / 2013 / Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection / Hepatology 58:98~107
Lai CL / 2013 / Prevention of hepatitis B virus-related hepatocellular carcinoma with antiviral therapy / Hepatology 57:399~408
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