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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 302 - 310 (9page)
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Background/Aims: Hepatitis C virus (HCV) replicates in the peripheral blood mononuclear cells (PBMCs), leading to the production of type I interferons (IFNs). It is well known that the gene expression profile of PBMC is similar to that of the liver. The present study explored the dynamic gene expression profile of PBMCs collected from HCV-infected patients undergoing direct-acting antiviral (DAA) therapy. Methods: A prospective cohort comprising 27 patients under DAA therapy was formed. Expression level of IFN-β and its downstream interferon-stimulated genes (ISGs) was measured in PBMCs before and after DAA treatment. Furthermore, immunoblotting was performed to identify the signaling molecules involved in the expression of ISGs. Results: The pretreatment expression level of interferon-induced protein 44 (IFI44) and C-X-C motif chemokine ligand 10 (CXCL10) correlated with the pretreatment expression level of IFN-β. After DAA treatment, a significant decrease in the expression levels of IFN-β, IFI44, and CXCL10 was observed in the PBMCs. Furthermore, the pretreatment expression level of IFN-β and ISGs correlated with the level of signal transducer and activator of transcription 1 (STAT1) phosphorylation, and DAA treatment abrogated STAT1 phosphorylation. Conclusions: Pretreatment activation of IFN-β response is rapidly normalized after DAA treatment. The present study suggests that the decreased type I IFN response by the clearance of HCV might contribute to DAA-induced alleviation of extrahepatic manifestation of chronic HCV infection.
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참고문헌 (34)
참고문헌 신청
Thrift AP / 2017 / Global epidemiology and burden of HCV infection and HCV-related disease / Nat Rev Gastroenterol Hepatol 14:122~132
Shin EC / 2016 / Immune responses and immunopathology in acute and chronic viral hepatitis / Nat Rev Immunol 16:509~523
Ramos-Casals M / 2017 / Evidence-based recommendations on the management of extrahepatic manifestations of chronic hepatitis C virus infection / J Hepatol 66:1282~1299
Stark GR / 2012 / The JAK-STAT pathway at twenty / Immunity 36:503~514
Borden EC / 2007 / Interferons at age 50: past, current and future impact on biomedicine / Nat Rev Drug Discov 6:975~990
Shin EC / 2016 / Immune responses and immunopathology in acute and chronic viral hepatitis / Nat Rev Immunol 16:509~523
Ramos-Casals M / 2017 / Evidence-based recommendations on the management of extrahepatic manifestations of chronic hepatitis C virus infection / J Hepatol 66:1282~1299
Stark GR / 2012 / The JAK-STAT pathway at twenty / Immunity 36:503~514
Borden EC / 2007 / Interferons at age 50: past, current and future impact on biomedicine / Nat Rev Drug Discov 6:975~990
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