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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 268 - 274 (7page)
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Objective This study investigates the association between mental disorders and interferon nontreatment in patients with chronic hepatitis C virus (HCV) infection in a large national sample. Methods Using the National Health Insurance Research Database of Taiwan, we conducted a nationwide population-based study. Each case was matched to five controls by age, sex, urbanization, and income. Conditional logistic regression was used to assess odds of HCV nontreatment in different mental disorders. Results From 1999 to 2013, we identified 92,970 subjects with HCV infection and 15,495 HCV cases (16.7%) had received IFN therapy. Other than chronic obstructive pulmonary disease, the medical diseases and mental disorders were significantly different between IFN and non-IFN treated HCV patients. After adjusting for medical diseases, depressive disorder and anxiety disorder was positively associated with receiving IFN therapy. Patients with schizophrenia, bipolar disorders and alcohol use disorders were significantly less likely to receive interferon. Antidepressant exposure (cumulative daily exposure or cumulative daily dose) was associated with lower odds of IFN treatment. Conclusion Our nationwide cohort study demonstrated that INF nontreatment rate was lower in certain mental disorders. Antidepressant exposure might lower the chance of receiving IFN treatment. Our results may help to identify and to overcome the obstacles for HCV treatment and further apply to DAAs regimen.
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참고문헌 (37)
참고문헌 신청
Poynard T / 2003 / Viral hepatitis C / Lancet 362:2095~2100
Shiffman ML / 2009 / Effect of HCV RNA suppression during peginterferon alfa-2a maintenance therapy on clinical outcomes in the HALT-C trial / Gastroenterology 137:1986~1994
NIH Consensus Statement on Management of Hepatitis C / 2002 / NIH Consens State Sci Statements 19:1~46
Okanoue T / 2005 / Natural course of asymptomatic hepatitis C virus-infected patients and hepatocellular carcinoma after interferon therapy / Clin Gastroenterol Hepatol 3:S89~S91
Chu CJ / 2008 / Hepatitis B virus/hepatitis C virus coinfection : epidemiology, clinical features, viral interactions and treatment / J Gastroenterol Hepatol 23:512~520
Shiffman ML / 2009 / Effect of HCV RNA suppression during peginterferon alfa-2a maintenance therapy on clinical outcomes in the HALT-C trial / Gastroenterology 137:1986~1994
NIH Consensus Statement on Management of Hepatitis C / 2002 / NIH Consens State Sci Statements 19:1~46
Okanoue T / 2005 / Natural course of asymptomatic hepatitis C virus-infected patients and hepatocellular carcinoma after interferon therapy / Clin Gastroenterol Hepatol 3:S89~S91
Chu CJ / 2008 / Hepatitis B virus/hepatitis C virus coinfection : epidemiology, clinical features, viral interactions and treatment / J Gastroenterol Hepatol 23:512~520
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