지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 207 - 217 (11page)
이용수
초록· 키워드
오류제보하기
Background/Aims: This study aimed to elucidate the epidemiological and clinical characteristics of chronic hepatitis C (CHC) patients in South Korea from 2007 to 2017 and to compare the treatment patterns between two periods before and after the first approval of direct-acting antivirals (DAA) in South Korea in 2015. Methods: This prospective, multicenter cohort enrolled 2,758 patients with hepatitis C virus (HCV) viremia at seven tertiary centers, and clinical data were prospectively collected with questionnaire surveys focused on lifetime risk factors related to HCV infection. Results: The HCV patients had a mean age of 57.3 years (50.8% male). Among them, 14.3% showed a positive history of transfusion before HCV screening and 5.6% reported intravenous drug use (IVDU), with significant differences in these risk factors between men and women. The proportions of patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC) were 69.5%, 18.9%, and 11.5%, respectively. The mean alanine aminotransaminase level was within the upper normal limit at 49.9%, and the major genotypes were 1b (48.2%) and 2 (46.4%). The overall treatment rate was 53.8%, showing a rapid transition from interferon-based therapy to DAA therapy. In the post-DAA-approval era, the untreated group was older, had a higher prevalence of HCC, and had less education than the treated group. Conclusions: More than 90% of CHC patients were over 40 years old, the major genotypes were 1b and 2, and IVDU was observed in less than 6% of CHC patients. Approximately half of the patients underwent antiviral therapy even in the DAA era, showing an unmet need with regard to HCV elimination.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Lavanchy D / 2011 / Evolving epidemiology of hepatitis C virus / Clin Microbiol Infect 17:107~115
El-Serag HB / 2012 / Epidemiology of viral hepatitis and hepatocellular carcinoma / Gastroenterology 142:1264~1273
Wong MCS / 2019 / The changing epidemiology of liver diseases in the Asia-Pacific region / Nat Rev Gastroenterol Hepatol 16:57~73
Hajarizadeh B / 2013 / Epidemiology and natural history of HCV infection / Nat Rev Gastroenterol Hepatol 10:553~562
World Health Organization (WHO) / Global health sector strategy on viral hepatitis 2016-2021: towards ending viral hepatitis
El-Serag HB / 2012 / Epidemiology of viral hepatitis and hepatocellular carcinoma / Gastroenterology 142:1264~1273
Wong MCS / 2019 / The changing epidemiology of liver diseases in the Asia-Pacific region / Nat Rev Gastroenterol Hepatol 16:57~73
Hajarizadeh B / 2013 / Epidemiology and natural history of HCV infection / Nat Rev Gastroenterol Hepatol 10:553~562
World Health Organization (WHO) / Global health sector strategy on viral hepatitis 2016-2021: towards ending viral hepatitis
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Unmet needs of chronic hepatitis C in the era of direct-acting antiviral therapy
Clinical and Molecular Hepatology
2020 .01
-
The impact of unrestricted access to direct-acting antiviral among incarcerated hepatitis C virus-infected patients
Clinical and Molecular Hepatology
2021 .01
-
Recent update of the 2017 Korean Association for the Study of the Liver (KASL) treatment guidelines of chronic hepatitis C: Comparison of guidelines from other continents, 2017 AASLD/IDSA and 2016 EASL
Clinical and Molecular Hepatology
2018 .01
-
Therapy with Direct-Acting Antiviral Agents for Hepatitis C-Related Liver Cirrhosis
Gut and Liver
2017 .01
-
Interferon-free treatment for hepatitis C virus infection induces normalization of extrahepatic type I interferon signaling
Clinical and Molecular Hepatology
2018 .01
-
Correspondence on Letter regarding “Toward hepatitis C virus elimination using artificial intelligence”
Clinical and Molecular Hepatology
2024 .04
-
Next-generation sequencing analysis of hepatitis C virus resistance–associated substitutions in direct-acting antiviral failure in South Korea
Clinical and Molecular Hepatology
2023 .04
-
Direct-acting antivirals response in hepatocellular carcinoma: Does the presence of hepatocellular carcinoma matter?
Clinical and Molecular Hepatology
2019 .01
-
Direct Anterior Approach in Total Hip Arthroplasty: A Single Center Experience
Hip and Pelvis
2024 .09
-
일반 수술 침대와 짧은 대퇴 주대를 이용한 인공 고관절 전 치환술의 직접 전방 도달법과 변형된 전 측방 도달법에 따른 결과 비교
대한정형외과학회지
2019 .06
-
Unmet needs in the post-direct-acting antivirals era: The risk and molecular mechanisms of hepatocellular carcinoma after hepatitis C virus eradication
Clinical and Molecular Hepatology
2024 .07
-
Barriers to treatment of failed or interferon ineligible patients in the era of DAA: single center study
Clinical and Molecular Hepatology
2017 .01
-
Final Report of Unmet Needs of Interferon-Based Therapy for Chronic Hepatitis C in Korea: Basis for Moving into the Direct-Acting Antiviral Era
Gut and Liver
2017 .07
-
Treatment Outcomes of HCV Infection in People Living with HIV: A Case Series from a Single Center in Korea
Infection and Chemotherapy
2024 .09
-
Treatment Response and Long-Term Outcome of Peginterferon α and Ribavirin Therapy in Korean Patients with Chronic Hepatitis C
Gut and Liver
2016 .01
-
Quality of Life of Chronic Hepatitis C Patients and Its Associated Factors
Osong Public Health and Research Persptectives
2017 .01
-
Comparison of the Clinical Characteristics and Outcomes between Leprosy-Affected Persons in Sorokdo and the General Population Affected by Chronic Hepatitis C in Korea
Gut and Liver
2019 .01
-
Real-World Clinical Efficacy and Tolerability of Direct-Acting Antivirals in Hepatitis C Monoinfection Compared to Hepatitis C/Human Immunodeficiency Virus Coinfection in a Community Care Setting
Gut and Liver
2018 .01
-
What is the Long-term Benefit of Direct-acting Antiviral Therapy in Chronic Hepatitis C?
Journal of Korean Medical Science
2019 .01
-
Management of hepatitis C viral infection in chronic kidney disease patients on hemodialysis in the era of direct-acting antivirals
Clinical and Molecular Hepatology
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0