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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 26 - 32 (7page)
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Purpose: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. It has been shown that memory deficits is common in patients with MS. Recent studies using experimental autoimmune encephalomyelitis (EAE) as an animal model of MS have shown that indicated that EAE causes hippocampal-dependent impairment in learning and memory. Thus far, there have been no in vivo electrophysiological reports describing synaptic transmission in EAE animals. The aim of the present work is to evaluate the synaptic changes in the CA1 region of the hippocampus of EAE rats.
Methods: To evaluate changes in synaptic transmission in the CA1 region of the hippocampus of EAE rats, field excitatory postsynaptic potentials (fEPSPs) from the stratum radiatum of CA1 neurons, were recorded following Schaffer collateral stimulation.
Results: The results showed that EAE causes deficits in synaptic transmission and long-term potentiation (LTP) in the hippocampus.
In addition, paired-pulse index with a 120 msec interstimulus interval was decreased in the EAE group. These findings indicate that EAE might induce suppression in synaptic transmission and LTP by increasing the inhibitory effect of GABAB receptors on the glutamate-mediated EPSP.
Conclusions: In conclusion, influence of inflammation-triggered mechanisms on synaptic transmission may explain the negative effect of EAE on learning abilities in rats.
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참고문헌 (21)
참고문헌 신청
Lassmann H / 2001 / Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy / Trends Mol Med 7:115~121
Calabrese P / 2006 / Neuropsychology of multiple sclerosis: an overview / J Neurol 253(Suppl 1):I10~I15
Rao SM / 1991 / Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction / Neurology 41:685~691
Vereker E / 2000 / The inhibitory effect of interleukin-1beta on long-term potentiation is coupled with increased activity of stress-activated protein kinases / J Neurosci 20:6811~6819
Papadopoulos D / 2009 / Substantial archaeocortical atrophy and neuronal loss in multiple sclerosis / Brain Pathol 19:238~253
Calabrese P / 2006 / Neuropsychology of multiple sclerosis: an overview / J Neurol 253(Suppl 1):I10~I15
Rao SM / 1991 / Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction / Neurology 41:685~691
Vereker E / 2000 / The inhibitory effect of interleukin-1beta on long-term potentiation is coupled with increased activity of stress-activated protein kinases / J Neurosci 20:6811~6819
Papadopoulos D / 2009 / Substantial archaeocortical atrophy and neuronal loss in multiple sclerosis / Brain Pathol 19:238~253
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