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논문 기본 정보

자료유형
학술저널
저자정보
Jinhee Oh (Kyung Hee University) Yujeong Ha (Kyung Hee University) Tae Woo Kwon (Kyung Hee University) Hyo-Sung Jo (Kyung Hee University) Sang-Kwan Moon (Kyung Hee University) Yoonsung Lee (Kyung Hee University) Seung-Yeol Nah (Kyung Hee University) Min Soo Kim (Korea Institute of Science and Technology) Ik-Hyun Cho (Kyung Hee University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.49 No.1
발행연도
2025.1
수록면
53 - 63 (11page)

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초록· 키워드

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Background: The non-saponin (NS) fraction is an important active component of Panax ginseng, with multi-functional pharmacological activities including neuroprotective, immune regulatory, anti-inflammatory, and antioxidant effects. However, the effects of NSs on multiple sclerosis (MS), a chronic and autoimmune demyelinating disorder, have not yet been demonstrated.
Purpose: and Methods: The goal of the present study was to demonstrate the pharmacological actions of NSs on movement dysfunctions and the related mechanisms of action using an experimental autoimmune encephalomyelitis (EAE) mouse model of MS.
Results: NSs (p.o.) alleviated movement dysfunctions in EAE mice related to reduced demyelination in the lumbar spinal cord (LSC). NSs attenuated the recruitment of microglia (CD11b+/CD45<sup>low</sup>) and macrophages (CD11b+/CD45<sup>high</sup>) in LSCs from EAE model mice, consistent with the decreased mRNA expression levels of the main proinflammatory mediators (IL-1β, COX-2, MCP-1, MIP-1α, and RANTES). NSs blocked the migration of Th17 cells (CD4+/IL17A+) and mRNA expression levels of IL-17A (product of Th17 cells) in LSCs from EAE mice. NSs suppressed alterations in blood-brain barrier (BBB) components, such as astrocytes and cell adhesion molecules, associated with inhibiting NF-κB and p38 MAPK pathways in LSCs of EAE mice and lipopolysaccharide-induced bEND.3 cells.
Conclusions: NSs could attenuate movement dysfunctions and related pathological/inflammatory changes by reducing BBB permeability through NF-κB and p38 MAPK pathway inhibition in LSCs of EAE model mice. These are the first results suggesting that NSs can be potential therapeutic agents for MS by reducing BBB permeability.

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ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
5. Conclusion
References

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