지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 150 - 158 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Overactive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB. The α1-AR antagonists constitute a variety of drugs according to the receptor subtype affinity. This study investigated the efficacy of tamsulosin, naftopidil, and a combination of the two on OAB rats.
Methods: The OAB rat model was induced by an intraperitoneal injection of cyclophosphamide for 14 days. The experimental groups were divided into 5 groups: control group, OAB-induction group, OAB-induction and tamsulosin monotherapy group, OAB-induction and naftopidil monotherapy group, and OAB-induction and tamsulosin-naftopidil combination therapy group. For the drug-treated groups, each drug was administrated for 14 days after the OAB induction. Cystometry for urodynamic evaluation and immunohistochemical stain for c-Fos and nerve growth factor (NGF) expressions in the central micturition centers were performed.
Results: Increased contraction pressure and time with enhanced c-Fos and NGF expressions in the central micturition centers were found in the OAB rats. Tamsulosin suppressed contraction pressure and time while inhibiting c-Fos and NGF expressions.
Naftopidil showed no significant effect and combination therapy showed less of an effect on contraction pressure and time. Naftopidil and combination therapy exerted no significant effect on the c-Fos and NGF expressions.
Conclusions: Tamsulosin showed the most prominent efficacy for the treatment of OAB compared to the naftopidil and combination.
The combination of tamsulosin with naftopidil showed no synergistic effects on OAB; however, further studies of addon therapy might provide opportunities to find a new modality.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Overactive Bladder Symptoms Negatively Affect Sleep Quality of Patients With Depression
International Neurourology Journal
2021 .01
-
Prevalence, Risk Factors, and Psychological Effects of Overactive Bladder in Chinese University Students
International Neurourology Journal
2022 .12
-
Add-on Therapy With the α-Blockers Tamsulosin and Naftopidil Improves Voiding Function by Enhancing Neuronal Activity in Prostatic Hyperplasia Rats
International Neurourology Journal
2018 .01
-
Urodynamic and Bladder Diary Factors Predict Overactive Bladderwet in Women: A Comparison With Overactive Bladder-dry
International Neurourology Journal
2019 .01
-
Risk factors and factors affecting the severity of overactive bladder symptoms in Korean women who use public health centers
Obstetrics & Gynecology Science
2018 .01
-
Persistence and compliance with medication management in the treatment of overactive bladder
Investigative and Clinical Urology
2016 .01
-
Effects of Overactive Bladder Symptoms in Stroke Patients’ Health Related Quality of Life and Their Performance Scale
Annals of Rehabilitation Medicine
2017 .01
-
Clinical Efficacy of Solifenacin in the Management of Diabetes Mellitus-Associated Versus Idiopathic Overactive Bladder Symptoms: A Multicenter Prospective Study
International Neurourology Journal
2018 .01
-
Evaluation of Overactive Bladder in Male Antidepressant Users: A Prospective Study
International Neurourology Journal
2017 .01
-
Updates of Overactive Bladder in Pediatrics
International Neurourology Journal
2023 .03
-
The Overactive Bladder Symptom Score, International Prostate Symptom Score–Storage Subscore, and Urgency Severity Score in Patients With Overactive Bladder and Hypersensitive Bladder: Which Scoring System is Best?
International Neurourology Journal
2018 .01
-
Potential Biomarkers for Diagnosis of Overactive Bladder Patients: Urinary Nerve Growth Factor, Prostaglandin E2, and Adenosine Triphosphate
International Neurourology Journal
2017 .01
-
NGF and HB-EGF: Potential Biomarkers that Reflect the Effects of Fesoterodine in Patients with Overactive Bladder Syndrome
Yonsei Medical Journal
2015 .01
-
Clinical Manifestations of Overactive Bladder With Migraine as a Comorbidity: A Prospective Cross-Sectional Study
International Neurourology Journal
2020 .01
-
In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats
International Neurourology Journal
2019 .01
-
Potential Role of Monocyte Chemoattractant Protein-1 in Monitoring Disease Progression and Response to Treatment in Overactive Bladder Patients
International Neurourology Journal
2020 .01
-
Intravesical Sodium Chondroitin Sulphate to Treat Overactive Bladder: Preliminary Result
International Neurourology Journal
2015 .01
-
Role of Transcutaneous Electrical Nerve Stimulation in Treating Children With Overactive Bladder From Pooled Analysis of 8 Randomized Controlled Trials
International Neurourology Journal
2020 .01
-
Assessment of Proportion of Hidden Patients Having Symptoms of Overactive Bladder and Why Has It Been Hidden in Female Outpatients Admitted to Hospital
International Neurourology Journal
2016 .01
-
Fecal Retention in Overactive Bladder (OAB) in Children: Perspective of a Pediatric Gastroenterologist
Childhood Kidney Diseases
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0