지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 20 - 29 (10page)
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초록· 키워드
오류제보하기
Purpose: Benign prostatic hyperplasia (BPH) impacts quality of life in men by causing lower urinary tract symptoms. α1- Adrenoceptor (α1-AR) blockers improve lower urinary tract symptoms. We investigated the efficacy of add-on therapy with α1-AR blockers on BPH rats. Methods: Rats in the drug-treated groups were orally administered each drug once a day for 30 days after orchiectomy. To induce BPH, rats were castrated and testosterone (20 mg/kg) was injected subcutaneously once per day for 30 days. Cystometry was conducted to measure voiding contraction pressure and the interval contraction time, immunohistochemistry was performed to measure c-Fos and nerve growth factor (NGF) expression in the neuronal voiding centers, and nicotinamide adenine dinucleotide phosphate-diaphorase histochemistry was used to measure nitric oxide synthase (NOS) expression. Results: Orchiectomy and testosterone injection decreased voiding contraction pressure and the interval contraction time, suggesting BPH symptoms. Voiding contraction pressure and the interval contraction time were greater in the group that received the combination treatment (tamsulosin with naftopidil) than in the tamsulosin monotherapy or naftopidil monotherapy groups. c-Fos, NGF, and NOS expression in the neuronal voiding centers was enhanced by BPH induction. c-Fos, NGF, and NOS expression was suppressed by the combination treatment (tamsulosin with naftopidil) to a greater extent than was the case for tamsulosin monotherapy or naftopidil monotherapy. Conclusions: Combination therapy of tamsulosin and naftopidil showed greater efficacy for the treatment of BPH than tamsulosin monotherapy or naftopidil monotherapy; therefore, combination therapy can be considered as a novel therapeutic method for BPH.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Ishii K / 2014 / Identification of a new pharmacological activity of the phenylpiperazine d erivative naftopidil: tubulin-binding drug / J Chem Biol 8:5~9
Fowler CJ / 2006 / Integrated control of lower urinary tract--clinical perspective / Br J Pharmacol 147(Suppl 2):S14~S24
Ku JH / 2010 / Correlation between prostatic urethral angle and bladder outlet obstruction index in patients with lower urinary tract symptoms / Urology 75:1467~1471
Kang M / 2014 / Association of high bladder neck elevation with urodynamic bladder outlet obstruction in patients with lower urinary tract symptoms and benign prostatic hyperplasia / Urology 84:1461~1466
Kawai Y / 2016 / Effects of the phosphodiesterase 5 inhibitor Tadalafil on bladder function in a rat model of partial bladder outlet obstruction / Neurourol Urodyn 35:444~449
Fowler CJ / 2006 / Integrated control of lower urinary tract--clinical perspective / Br J Pharmacol 147(Suppl 2):S14~S24
Ku JH / 2010 / Correlation between prostatic urethral angle and bladder outlet obstruction index in patients with lower urinary tract symptoms / Urology 75:1467~1471
Kang M / 2014 / Association of high bladder neck elevation with urodynamic bladder outlet obstruction in patients with lower urinary tract symptoms and benign prostatic hyperplasia / Urology 84:1461~1466
Kawai Y / 2016 / Effects of the phosphodiesterase 5 inhibitor Tadalafil on bladder function in a rat model of partial bladder outlet obstruction / Neurourol Urodyn 35:444~449
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