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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 18 - 22 (5page)
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Cytomegalovirus (CMV) reactivation in immune compromised patients such as those undergoing hematopoietic progenitor cell transplantation (HPCT) and those with HIV infections can cause severe morbidity and mortality despite treatment with appropriate antiviral agents. The recovery of Cytomegalovirus (CMV) specific cytotoxic T lymphocytes (CTL) plays an important role in the reconstitution of CMV specific immunity in immunocompromised patients. Recent studies have reported that CMV reactivation can be successfully treated by adoptive transfer of CMV-specific T cell clones from CMV seropositive donors expanded in vitro with CMV infected fibroblasts or lysates of CMV infected cells. Other studies have used immune dominant CMV proteins or peptides to expand CMV-specific cytotoxic T lymphocytes. This review describes the clinical manifestations of CMV disease in immunocompromised patients, recent advances of antiviral therapy for CMV disease, the principals of the induction of cellular immune response to CMV, and the clinical application of CMV immunotherapy.
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참고문헌 (27)
참고문헌 신청
/ 1978 / Sequence of protein synthesis in cells infected by human cytomegalovirus: early and late virus-induced polypeptides 26 : 686 ~ 701
/ 1991 / Class I MHC-restricted cytotoxic T-lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expression 146 : 2795 ~
/ 1991 / Development of a treatment regimen for human cytomegalovirus (CMV) infection in bone marrow transplantation recipients by adoptive transfer of donor- derived CMV-sp
/ 1991 / Outcome of confirmed symptomatic congenital cytomegalovirus infection 66 : 1068 ~ 1069
/ 1992 / The lower matrix protein pp65 is the principal viral antigen present in peripheral blood leukocytes during an active cytomegalovirus infection 73 : 2923 ~ 2932
/ 1991 / Class I MHC-restricted cytotoxic T-lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expression 146 : 2795 ~
/ 1991 / Development of a treatment regimen for human cytomegalovirus (CMV) infection in bone marrow transplantation recipients by adoptive transfer of donor- derived CMV-sp
/ 1991 / Outcome of confirmed symptomatic congenital cytomegalovirus infection 66 : 1068 ~ 1069
/ 1992 / The lower matrix protein pp65 is the principal viral antigen present in peripheral blood leukocytes during an active cytomegalovirus infection 73 : 2923 ~ 2932
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Comparison of Quantitation of Cytomegalovirus DNA by Real-Time PCR in Whole Blood with the Cytomegalovirus Antigenemia Assay
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