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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 75 - 80 (6page)
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초록· 키워드
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Purpose: To investigate the frequency, presentation, management, and outcome of cytomegalovirus (CMV) infection in pediatric patients who underwent renal transplantation.
Methods: We performed a retrospective chart review of 70 patients under the age of 18, who underwent renal transplantation between January 1990 and November 2014. A diagnosis of CMV infection was based on serology, molecular assays, antigenemia assays, and culture. CMV infection was defined as detection of virus and CMV disease was diagnosed when clinical signs and symptoms were present.
Results: The number of patients with CMV infection was 18 (25.7% of renal transplant recipients). Twelve were male (66.7%), and the mean±standard deviation (SD) age at infection was 13.3±3.9 years. Median time of infection after renal transplantation was 4 months (range 1.0-31.0 months). Pretransplantation CMV status in the infected group was as follows: donor (D)+/recipient (R)+, 11 (61.1%); D+/R-, 7 (38.9%); D-/R+, 0; and D-/R- 0. Nine patients had CMV disease with fever, leukopenia, thrombocytopenia, or organ involvement such as enteritis, hepatitis, and pneumonitis. The age of disease occurrence was 13.1±3.9 years and the median time to disease onset after renal transplantation was 8 months (range 1.0-31.0).
Immunosuppressive agents were reduced or discontinued in 14 patients (77.8%), antiviral agents were used in 11 patients (61.1%), and all patients with CMV infection were controlled.
Conclusions: A quarter of the patients had CMV infection about 4 months after renal transplantation. CMV infection was successfully treated with reduction of immunosuppressants or with antiviral agents.
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참고문헌 (20)
참고문헌 신청
Bhadauria D / 2012 / Cytomegalovirus disease in renal transplant recipients: a single-center experience / Indian J Microbiol 52 : 510 ~ 515
Camacho-Gonzalez AF / 2011 / 24 weeks of valganciclovir prophylaxis in children after renal transplantation: a 4-year experience / Transplantation 91 : 245 ~ 250
Carstens J / 2006 / Cytomegalovirus infection in renal transplant recipients / Transpl Infect Dis 8 : 203 ~ 212
Cordero E / 2012 / Cytomegalovirus disease in kidney transplant recipients: incidence, clinical profile, and risk factors / Transplant Proc 44 : 694 ~ 700
Corona-Nakamura AL / 2009 / Incidence and predictive factors for cytomegalovirus infection in renal transplant recipients / Transplant Proc 41 : 2412 ~ 2415
Camacho-Gonzalez AF / 2011 / 24 weeks of valganciclovir prophylaxis in children after renal transplantation: a 4-year experience / Transplantation 91 : 245 ~ 250
Carstens J / 2006 / Cytomegalovirus infection in renal transplant recipients / Transpl Infect Dis 8 : 203 ~ 212
Cordero E / 2012 / Cytomegalovirus disease in kidney transplant recipients: incidence, clinical profile, and risk factors / Transplant Proc 44 : 694 ~ 700
Corona-Nakamura AL / 2009 / Incidence and predictive factors for cytomegalovirus infection in renal transplant recipients / Transplant Proc 41 : 2412 ~ 2415
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