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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 161 - 175 (15page)
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The current cytomegalovirus (CMV) prevention strategies in solid organ transplantation (SOT) recipients have contributed towards overcoming the detrimental effects caused by CMV lytic infection, and improving the long-term success rate of graft survival. Although the quantification of CMV in peripheral blood is the standard method, and an excellent end-point for diagnosing CMV replication and modulating the anti-CMV prevention strategies in SOT recipients, a novel biomarker mimicking the CMV control mechanism is required. CMV-specific immune monitoring can be employed as a basic tool predicting CMV infection or disease after SOT, since uncontrolled CMV replication mostly originates from the impairment of immune responses against CMV under immunosuppressive conditions in SOT recipients. Several studies conducted during the past few decades have indicated the possibility of measuring the CMV-specific cell-mediated immune response in clinical situations. Among several analytical assays, the most advancing standardized tool is the QuantiFERON®-CMV assay. The T-Track® CMV kit that uses the standardized enzyme-linked immunospot assay is also widely employed. In addition to these assays, immunophenotyping and intracellular cytokine analysis using flow cytometry (with fluorescence-labeled monoclonal antibodies or peptide-major histocompatibility complex multimers) needs to be adequately standardized and validated for potential clinical applications.
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참고문헌 (23)
참고문헌 신청
Arthurs SK / 2008 / Delayed-onset primary cytomegalovirus disease and the risk of allograft failure and mortality after kidney transplantation / Clin Infect Dis 46 : 840 ~ 8
Borchers AT / 1999 / Role of cytomegalovirus infection in allograft rejection: a review of possible mechanisms / Transpl Immunol 7 : 75 ~ 82
Evans PC / 2000 / An association between cytomegalovirus infection and chronic rejection after liver transplantation / Transplantation 69 : 30 ~ 35
Fisher RA / 2009 / Cytomegalovirus infection and disease in the new era of immunosuppression following solid organ transplantation / Transpl Infect Dis 11 : 195 ~ 202
Fishman JA / 1998 / Infection in organ-transplant recipients / N Engl J Med 338 : 1741 ~ 1751
Borchers AT / 1999 / Role of cytomegalovirus infection in allograft rejection: a review of possible mechanisms / Transpl Immunol 7 : 75 ~ 82
Evans PC / 2000 / An association between cytomegalovirus infection and chronic rejection after liver transplantation / Transplantation 69 : 30 ~ 35
Fisher RA / 2009 / Cytomegalovirus infection and disease in the new era of immunosuppression following solid organ transplantation / Transpl Infect Dis 11 : 195 ~ 202
Fishman JA / 1998 / Infection in organ-transplant recipients / N Engl J Med 338 : 1741 ~ 1751
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