지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 597 - 613 (17page)
이용수
초록· 키워드
오류제보하기
Carcinoma of the uterine cervix is one of the most common malignancies among women worldwide. Human papillomaviruses (HPV) have been identified as the major etiological factor in cervical carcinogenesis. However, the time lag between HPV infection and the diagnosis of cancer indicates that multiple steps, as well as multiple factors, may be necessary for the development of cervical cancer. The development and progression of cervical carcinoma have been shown to be dependent on various genetic and epigenetic events, especially alterations in the cell cycle checkpoint machinery. In mammalian cells, control of the cell cycle is regulated by the activity of cyclin-dependent kinases (CDKs) and their essential activating coenzymes, the cyclins. Generally, CDKs, cyclins, and CDK inhibitors function within several pathways, including the p16INK4A-cyclin D1-CDK4/6-pRb-E2F, p21WAF1- p27KIP1-cyclinE-CDK2, and p14ARF-MDM2-p53 pathways. The results from several studies showed aberrant regulation of several cell cycle proteins, such as cyclin D, cyclin E, p16 INK4A, p21WAF1, and p27KIP1, as characteristic features of HPV- infected and HPV E6/E7 oncogene-expressing cervical carcinomas and their precursors. These data suggested further that interactions of viral proteins with host cellular proteins, particularly cell cycle proteins, are involved in the activation or repression of cell cycle progression in cervical carcinogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
/ 1982-6. / Sidransky D. Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clin Cancer Res 2001
/ 1995 / Dipaolo JA. CDKN2 in HPV-positive and HPV- negative cervical-carcinoma cell lines. : 226 ~ 30
/ 1996 / gene is not altered in uterine cervical carcinomas or cell lines. : 16 26 ~ 31
/ 1997 / Kim JW. Correlation between G1 cyclins and HPV in the uterine cervix. : 339 ~ 47
/ 1998 / Herrington CS. Differential cell cycle regu
/ 1995 / Dipaolo JA. CDKN2 in HPV-positive and HPV- negative cervical-carcinoma cell lines. : 226 ~ 30
/ 1996 / gene is not altered in uterine cervical carcinomas or cell lines. : 16 26 ~ 31
/ 1997 / Kim JW. Correlation between G1 cyclins and HPV in the uterine cervix. : 339 ~ 47
/ 1998 / Herrington CS. Differential cell cycle regu
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
비소세포폐암종에서 Cyclin E 경로 단백들(cyclin E, cdk2,p21, p27, p57)의 발현 및 예후 지표 인자로서 의의
Journal of Pathology and Translational Medicine
2006 .01
-
Development of efficient detection methods of CDK2 (or 4) activities for mass screening
대한약학회 학술대회
2003 .01
-
자궁내막증에서 Cyclins-CDKs와 CDKIs에 의한세포주기 조절경로에 관한 연구
Obstetrics & Gynecology Science
2004 .01
-
HL60 세포주에서 방사선 조사에 의한 Apoptosis와 세포 주기 관련 유전자의 발현 변화
Radiation oncology journal : ROJ
1998 .01
-
Increased Expression of Cyclin D3 are Involved in Hepatocellular Carcinoma
Molecular & cellular toxicology
2008 .01
-
Overexpression of Cell Cycle Proteins of Peripheral Lymphocytes in Patients with Alzheimer’s Disease
PSYCHIATRY INVESTIGATION
2016 .01
-
Retinoic Acid Increases the Cell Cycle Progression of Human Gingival Fibroblasts by Increasing Cyclin E and CDK 2 Expression and Decreasing $p21^{WAF1/CIP1}$ and $p16^{INK4A}$ Expression
International Journal of Oral Biology
2012 .01
-
자궁목암종에서 Hypoxia Inducible Factor-1α의 발현과 Cyclin A1, Cyclin B1 발현 및 임상병리학적 인자들과의 연관성
Journal of Pathology and Translational Medicine
2009 .01
-
Synthesis and Anti-cancer Activity of Indirubin Derivatives as the CDK Inhibitors
대한약학회 학술대회
2003 .01
-
속단의 생리활성성분이 치은섬유아세포의 세포주기조절에 미치는 영향
Journal of Periodontal & Implant Science
2005 .01
-
Interrelation of Cyclin D1, Cyclin E, and p27Kip1 Expression on Tissue Arrays of Breast Cancer
Cancer Research and Treatment
2002 .01
-
Functional Inactivation of pRb Associated with Cyclin D1- and Cyclin-dependent Kinase 4 Overexpression Plays A Key Role in Human Pituitary Tumorigenesis
Journal of Pathology and Translational Medicine
2009 .01
-
Cadmium Induces Cell Cycle Arrest and Change in Expression of Cell Cycle Related Proteins in Breast Cancer Cell Lines
Toxicological Research
2005 .03
-
Glycogen synthase kinase 3β and cyclin D1 expression in cervical carcinogenesis
Obstetrics & Gynecology Science
2016 .01
-
Retinoic acid와 dibutyryl cyclic AMP가 F9 embryonic carcinoma cell 분화 중 G1 Phase 관련 분자에 미치는 영향
약학회지
1999 .01
-
유방암 조직에서 Cyclin D₁과 p16단백 발현의 임상적 의의
Annals of Surgical Treatment and Research
1999 .09
-
N-butyl- N-(4-hydroxybutyl)nitrosamine에 의한 흰쥐 방광암 발생 과정에서 세포주기 관련인자 단백(Cyclin D1, A, E, and B)의 발현
Journal of Pathology and Translational Medicine
2003 .01
-
Overexpression of Cyclin L2 Inhibits Growth and Enhances Chemosensitivity in Human Gastric Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
7-Chloro-4-nitro-benzo[1,2,5]oxadliazole 1-oxide의 CDK4 활성저해
약학회지
2006 .01
-
Prognostic Implications of Cyclin B1, p34cdc2, p27(Kip1) and p53 Expression in Gastric Cancer
Yonsei Medical Journal
2007 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0