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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 196 - 200 (5page)
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초록· 키워드
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The objective of this study was to investigate the correlation between factor XIII (FXIII) activity and disseminated intravascular coagulation (DIC) parameters and also to evaluate the clinical usefulness of DIC diagnosis. Citrated plasma from eighty patients with potential DIC was analyzed for FXIII activity. The primary patient conditions (48 male and 32 female, mean age, 51 years) were malignancy (n= 29), infection (n=25), inflammation (n=6), heart disease (n=3), thrombosis (n=2), injury (n=2), and other miscellaneous conditions (n=13). FXIII testing was performed using the CoaLinkTM FXIII Incorporation Assay Kit (PeopleBio Inc.). Among 80 patients who were suspected to have DIC based on clinical analysis, 46 (57.5%) fulfilled the overt DIC criteria (DIC score>=5) according to the International Society of Thrombosis and Haemostasis. FXIII levels in the plasma were significantly decreased in overt DIC compared to non-overt DIC patients (mean 75.1% and 199.7% respectively, p<0.0001). Interestingly, we found a significant inverse correlation between DIC scores and FXIII activity. In addition, FXIII activity significantly correlated with other hemostatic markers that included platelet count, prothrombin time, activated partial thromboplastin time, fibrinogen, and D-dimer. FXIII levels were significantly lower in patients with liver or renal dysfunction. In conclusion, FXIII cross-linking activity measurements may have differential diagnostic value as well as predictive value in patients who are suspected to have DIC.
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참고문헌 (16)
참고문헌 신청
/ / Antiplasmin drugs and factor XIII concentrates in the treatment of a patient with acute promyelocytic leukemia suga (w) : 1479 ~ 82
/ / Characterization of the gene for a subunit of human factor XIII : 5829 ~ 33
/ / Electron microscopy and hydrodynamic properties of factor XIII subunits : 551 ~ 6
/ 1996 / Changes of factor XIII a and b subunit in patients with disseminated intravascular coagulation syndrome 44 : 355 ~ 361
/ 1996 / Factor XIII deficiency: pathogenic mechanisms and clinical significance 22 : 419 ~ 425
/ / Characterization of the gene for a subunit of human factor XIII : 5829 ~ 33
/ / Electron microscopy and hydrodynamic properties of factor XIII subunits : 551 ~ 6
/ 1996 / Changes of factor XIII a and b subunit in patients with disseminated intravascular coagulation syndrome 44 : 355 ~ 361
/ 1996 / Factor XIII deficiency: pathogenic mechanisms and clinical significance 22 : 419 ~ 425
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