지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 169 - 177 (9page)
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초록· 키워드
오류제보하기
Puropose: The bladder outlet obstruction (BOO) causes a bladder hypertrophy and/or hyperplasia
with time. Heparin binding epidermal growth factor like growth factor (HB-EGF) is a potent mitogen
for bladder smooth muscle cell (BMSC), causing significant cellular hypertrophy. Few studies have
evaluated the effect of HB-EGF on bladder hypertrophy or hyperplasia. We studied to evaluated
the effect of HB-EGF on the hypertrophy or hyperplasia of human BSMC and fibroblast.
Material and methods: To evaluate the change of expression of HB-EGF mRNA of human BMSC
under a constant stimuli of 40cm-H20 pressure during 0, 1, 3 and 5 hours, RT-PCR was perfromed.
The human BMSC and bladder fibroblasts with the addition of the recombinant HB-EGF 25ng/ml
were performed 3H-thymidine and 3H-leucine incorporation assay for DNA and protein production,
respectively.
Results: The expression of HB-EGF mRNA in BMSC under a constant stimuli of 40cm-H20 pressure
was up-regulated with time (p<0.05). The optimal concentration of HB-EGF was 25ng/ml. The
3H-Lecine and 3H-thymidine activity in both human BSMC and fibroblast were significantly increased
in addition of 25ng/ml of HB-EGF (p<0.05 and p<0.05, respectively).
Conclusions: Constant hydrostatic pressure induces the expression of HB-EGF in human BSMC.
Subsequently HB-EGF induces hypertrophy and hyperplasia of human BSMC and fibroblast in
vitro. Our data support that HB-EGF is one of relevant BOO-induced growth factors. (J Korean
Continence Soc 2008;12:169-77)
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)]
Adam RM / 2004 / Shih S, Smith LEH, et al. Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells / Physiol Genomics 20 :
Backhaus BO / 2002 / Alterations in the molecular determinants of bladder compliance at hydrostatic pressures less than 40 cmH2O / J Urol 168 (6) : 2600 ~ 2604
Besner G / 1990 / Isolation and characterization of a macrophage-derived heparin-binding growth factor / Cell Regul 1 (11) : 811 ~ 819
Booz GW / 1995 / Molecular signalling mechanisms controlling growth and function of cardiac fibroblasts / Cardiovasc Res 30 (4) : 537 ~ 543
Adam RM / 2004 / Shih S, Smith LEH, et al. Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells / Physiol Genomics 20 :
Backhaus BO / 2002 / Alterations in the molecular determinants of bladder compliance at hydrostatic pressures less than 40 cmH2O / J Urol 168 (6) : 2600 ~ 2604
Besner G / 1990 / Isolation and characterization of a macrophage-derived heparin-binding growth factor / Cell Regul 1 (11) : 811 ~ 819
Booz GW / 1995 / Molecular signalling mechanisms controlling growth and function of cardiac fibroblasts / Cardiovasc Res 30 (4) : 537 ~ 543
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