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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 510 - 518 (9page)
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Purpose: The validity of tomotherapy-based simultaneous integrated boost (TOMOSIB)was assessed in terms of acute intestinal/urinary toxicity by comparing with 3-dimensional conformal radiotherapy (3DCRT) in cases of whole-pelvis radiation therapy (WPRT) for prostate cancer. Materials and Methods: Thirty-eight consecutivepatients who underwent curative WPRT were retrospectively reviewed. Twenty six (68.4%) received 3DCRT and the others (31.6%) were treated with TOMOSIB. A local boost to the prostate circumferential area was added to WPRT sequentially for 3DCRT and concomitantly for TOMOSIB. The total median prostate or prostatic bed dose was 64.8 Gy including median 45.0 Gy of WPRT. Acute toxicities were assessedaccording to RTOG criteria. Results: Overall intestinal toxicity was lower in TOMOSIB group than 3DCRT group (p=0.008). When it was divided into rectum and non-rectum intestine (NRI), TOMOSIB showed borderline superiority only in NRI toxicity (p=0.047). For the urinary toxicity, there was no significant difference between two groups (p=0.796). On dosimetric analysis for the rectum and bladder, dose delivered to 80% (p<0.001) and volume receiving 25‒40 Gy (p<0.001) were remarkably higher in 3DCRT. For the NRI, only maximum dose showed significant results between two groups (p<0.001). Conclusion: Intestinal toxicity should be verifiedwith more detailed anatomic categorization such as rectum and NRI. TOMOSIBcould not reduce urinary toxicity because of inevitably high dose exposure to the prostatic urethra. Current dosimetry system did not properly reflect intestinal/urinary toxicity, and suitable dosimetric guidelines are needed in TOMOSIB.
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참고문헌 (28)
참고문헌 신청
Keiler L / 2007 / Tomotherapy for prostate adenocarcinoma: a report on acute toxicity / Radiother Oncol 84:171~176
Zelefsky MJ / 2006 / Long-term outcome of high dose intensity modulated radiation therapy for patients with clinically localized prostate cancer / J Urol 176(4 Pt 1):1415~1419
Teh BS / 2001 / Intensity modulated radiation therapy (IMRT) following prostatectomy: more favorable acute genitourinary toxicity profile compared to primary IMRT for prostate cancer / Int J Radiat Oncol Biol Phys 49:465~472
Yoshimura R / 2006 / Acute and late genitourinary toxicity of conformal radiotherapy for prostate cancer / Radiat Med 24:553~559
Ishikawa H / 2008 / Adverse effects of androgen deprivation therapy on persistent genitourinary complications after carbon ion radiotherapy for prostate cancer / Int J Radiat Oncol Biol Phys 72:78~84
Zelefsky MJ / 2006 / Long-term outcome of high dose intensity modulated radiation therapy for patients with clinically localized prostate cancer / J Urol 176(4 Pt 1):1415~1419
Teh BS / 2001 / Intensity modulated radiation therapy (IMRT) following prostatectomy: more favorable acute genitourinary toxicity profile compared to primary IMRT for prostate cancer / Int J Radiat Oncol Biol Phys 49:465~472
Yoshimura R / 2006 / Acute and late genitourinary toxicity of conformal radiotherapy for prostate cancer / Radiat Med 24:553~559
Ishikawa H / 2008 / Adverse effects of androgen deprivation therapy on persistent genitourinary complications after carbon ion radiotherapy for prostate cancer / Int J Radiat Oncol Biol Phys 72:78~84
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