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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 440 - 446 (7page)
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초록· 키워드
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Purpose: Dermatofibrosarcoma protuberans (DFSP) carries a translocation resultingin the collagen type I alpha 1 (COL1A1)-platelet-derived growth factor beta (PDGFB) fusion gene, which is responsible for PDGFB activation. The purpose of this study is to evaluate the clinicopathological, genetic, and therapeutic features of DFSP in Korean patients. Materials and Methods: Clinicopathological featuresof 37 patients with DFSP were reviewed. Multiplex reverse transcriptase-polymerase chain reaction (PCR) was carried out in 16 patients using formalin-fixed, paraffin-embedded tissues and specific primers for COL1A1 and PDGFB. Results: The mean age of 37 patients was 37.4 years old. The most common tumor location was the trunk. All patients were treated primarily with surgery: 34 (91.7%) cases with Mohs micrographic surgery (MMS) and 3 (8.3%) cases with wide local excision. The median follow-up time was 33.7 months. Two patients, one in each treatment group, demonstrated local recurrence during the follow-up period. The COL1A1-PDGFB fusion gene was expressed in 14 (87.5%) cases, demonstrated by reverse transcriptase PCR analysis. No association was found among the differentCOL1A1-PDGFB fusion transcripts, the various histological subtypes and clinical features. Conclusion: Our results support the effectiveness of MMS in treating DFSP. The COL1A1-PDGFB fusion transcript was observed in 87.5% of patients. Therefore, COL1A1-PDGFB is a useful and accurate tool in diagnosing DFSP in Koreans.
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참고문헌 (22)
참고문헌 신청
Abbott JJ / 2006 / The prognostic significance of fibrosarcomatous transformation in dermatofibrosarcoma protuberans / Am J Surg Pathol 30 : 436 ~ 443
Bowne WB / 2000 / Dermatofibrosarcoma protuberans: a clinicopathologic analysis of patients treated and followed at a single institution / Cancer 88 : 2711 ~ 2720
Bridge JA / 1990 / Cytogenetic analysis of dermatofibrosarcoma protuberans / Cancer Genet Cytogenet 49 : 199 ~ 202
Chuang TY / 1990 / Incidence of cutaneous T cell lymphoma and other rare skin cancers in a defined population / J Am Acad Dermatol 23 (2 Pt 1) : 254 ~ 256
DuBay D / 2004 / Low recurrence rate after surgery for dermatofibrosarcoma protuberans: a multidisciplinary approach from a single institution / Cancer 100 : 1008 ~ 1016
Bowne WB / 2000 / Dermatofibrosarcoma protuberans: a clinicopathologic analysis of patients treated and followed at a single institution / Cancer 88 : 2711 ~ 2720
Bridge JA / 1990 / Cytogenetic analysis of dermatofibrosarcoma protuberans / Cancer Genet Cytogenet 49 : 199 ~ 202
Chuang TY / 1990 / Incidence of cutaneous T cell lymphoma and other rare skin cancers in a defined population / J Am Acad Dermatol 23 (2 Pt 1) : 254 ~ 256
DuBay D / 2004 / Low recurrence rate after surgery for dermatofibrosarcoma protuberans: a multidisciplinary approach from a single institution / Cancer 100 : 1008 ~ 1016
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