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학술저널
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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제56권 제2호
발행연도
2015.1
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375 - 381 (7page)

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Purpose: To investigate oncological outcomes based on bladder cuff excision (BCE) during radical nephroureterectomy (RNU) for upper tract urothelial carcinoma(UTUC) and to provide clinical evidence of tumor recurrence in patients without BCE. Materials and Methods: We retrospectively collected data of 372 consecutive patients who underwent RNU at our institution from May 1989 through October 2010. After excluding some data, we reviewed 336 patients for the analysis. Results: Of the patients who underwent RNU with BCE (n=279, 83.0%) and without BCE (n=57, 17.0%), patients without BCE had poorer cancer-specific and overall survival rates. Among 57 patients without BCE, 35 (61.4%) experienced tumor recurrence. Recurrence at the remnant ureter resulted in poor oncological outcomes compared to those in patients with bladder recurrence,but better outcomes were observed compared to recurrence at other sites. No significant predictors for tumor recurrence at the remnant ureter were identified. In patients without BCE, pathological T stage [hazard ratio (HR), 5.73] and lymphovascular invasion (HR, 3.65) were independent predictors of cancer-specificsurvival, whereas age (HR, 1.04), pathological T stage (HR, 5.11), and positivetumor margin (HR, 6.50) were independent predictors of overall survival. Conclusion: Patients without BCE had poorer overall and cancer-specific survivalafter RNU than those with BCE. Most of these patients experienced tumor recurrenceat the remnant ureter and other sites. Patients with non-organ confined UTUC after RNU without BCE may be considered for adjuvant chemotherapy with careful follow-up.

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