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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 433 - 439 (7page)
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초록· 키워드
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Purpose: To compare the efficacy of the new drug calfactant with the commonly used drugs surfactant-TA and poractant alfa. Materials and Methods: A total of 332 preterm infants at 24‒31 weeks’ gestation with respiratory distress syndrome (RDS) were enrolled and allocated to three groups according to the surfactant instilled;Group 1 (n=146, surfactant-TA), Group 2 (n=96, calfactant), and Group 3 (n=90, poractant alfa). The diagnosis of RDS and the decision to replace the pulmonarysurfactant were left to the attending physician and based on patient severitydetermined by chest radiography and blood gas analysis. Data were collected and reviewed retrospectively using patient medical records. Results: Demographic factors including gestational age, birth weight, Apgar score, clinical risk index for babies II score, and maternal status before delivery were not different between the study groups. Instances of surfactant redosing and pulmonary air leaks, as well as duration of mechanical ventilation, were also not different. Rates of patent ductus arteriosus, intraventricular hemorrhage (≥grade III), periventricular leukomalacia, high stage retinopathy of prematurity, necrotizing enterocolitis (≥stage II), and mortality were also similar, as was duration of hospital stay. Cases of pulmonary hemorrhage and moderate to severe bronchopulmonary dysplasia were increased in Group 3. Conclusion: Calfactant is equally as effective as surfactant-TA and poractantalfa. This was the first study comparing the efficacy of surfactant-TA, calfactant,and poractant alfa in a large number of preterm infants in Korea. Further randomized prospective studies on these surfactants are needed.
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참고문헌 (24)
참고문헌 신청
/ 1984 / An international classification of retinopathy of prematurity / Pediatrics 74 : 127 ~ 133
Engle WA / 2008 / Surfactant-replacement therapy for respiratory distress in the preterm and term neonate / Pediatrics 121 : 419 ~ 432
Fujiwara T / 1980 / Artificial surfactant therapy in hyaline-membrane disease / Lancet 1 : 55 ~ 59
Halliday HL / 2005 / History of surfactant from 1980 / Biol Neonate 87 : 317 ~ 322
Jobe A / 1983 / Respiratory distress syndrome--new therapeutic approaches to a complex pathophysiology / Adv Pediatr 30 : 93 ~ 130
Engle WA / 2008 / Surfactant-replacement therapy for respiratory distress in the preterm and term neonate / Pediatrics 121 : 419 ~ 432
Fujiwara T / 1980 / Artificial surfactant therapy in hyaline-membrane disease / Lancet 1 : 55 ~ 59
Halliday HL / 2005 / History of surfactant from 1980 / Biol Neonate 87 : 317 ~ 322
Jobe A / 1983 / Respiratory distress syndrome--new therapeutic approaches to a complex pathophysiology / Adv Pediatr 30 : 93 ~ 130
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