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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 823 - 828 (6page)
- DOI
- 10.3349/ymj.2017.58.4.823
이용수
초록· 키워드
오류제보하기
Purpose: Pulmonary surfactants for preterm infants contain mostly animal-derived surfactant proteins (SPs), which are essential for lowering surface tension. We prepared artificial pulmonary surfactants using synthetic human SP analogs and performed in vitro and in vivo experiments.
Materials and Methods: We synthesized peptide analogues that resemble human SP-B (RMLPQLVCRLVLRCSMD) and SP-C (CPVHLKRLLLLLLLLLLLLLLLL). Dipalmitoylphosphatidylcholine (DPPC), phosphatidylglycerol (PG), and palmitic acid (PA) were added and mixed in lyophilized to render powdered surfactant. Synsurf-1 was composed of DPPC:PG:PA:SP-B (75:25:10:3, w/w); Synsurf-2 was composed of DPPC:PG:PA:SP-C (75:25:10:3, w/w); and Synsurf-3 was composed of DPPC:PG:PA:SP-B:SP-C (75:25:10:3:3, w/w). We performed in vitro study to compare the physical characteristics using pulsating bubble surfactometer and modified Wilhelmy balance test. Surface spreading and adsorption test of the surfactant preparations were measured. In vivo test was performed using term and preterm rabbit pups. Pressure-volume curves were generated during the deflation phase. Histologicfindings were examined.
Results: Pulsating bubble surfactometer readings revealed following minimum and maximum surface tension (mN/m) at 5 minutes:Surfacten® (5.5±0.4, 32.8±1.6), Synsurf-1 (16.7±0.6, 28.7±1.5), Synsurf-2 (7.9±1.0, 33.1±1.6), and Synsurf-3 (7.1±0.8, 34.5±1.0). Surface spreading rates were as follows: Surfacten® (27 mN/m), Synsurf-1 (43 mN/m), Synsurf-2 (27 mN/m), and Synsurf-3 (27 mN/m). Surface adsorption rate results were as follows: Surfacten® (28 mN/m), Synsurf-1 (35 mN/m), Synsurf-2 (29 mN/m), and Synsurf-3 (27 mN/m). The deflation curves were best for Synsurf-3; those for Synsurf-2 were better than those for Surfacten®. Synsurf-1 was the worst surfactant preparation. Microscopic examination showed the largest aerated area of the alveoli in the Synsurf-3 group, followed by Synsurf-1 and Surfacten®; Synsurf-2 was the smallest.
Conclusion: Synsurf-3 containing both SP-B and SP-C synthetic analogs showed comparable and better efficacy than commerciallyused Surfacten® in lowering surface tension, pressure-volume curves, and tissue aerated area of the alveoli.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Jobe AH / 2008 / Injury and inflammation from resuscitation of the preterm infant / Neonatology 94:190~196
Miedema M / 2011 / Changes in lung volume and ventilation during surfactant treatment in ventilated preterm infants / Am J Respir Crit Care Med 184:100~105
Fujiwara T / 1980 / Artificial surfactant therapy in hyaline-membrane disease / Lancet 1:55~59
Soll R / 2009 / Multiple versus single doses of exogenous surfactant for the prevention or treatment of neonatal respiratory distress syndrome / Cochrane Database Syst Rev (1):CD000141
김성미 / 2014 / Early Prophylactic versus Late Selective Use of Surfactant for Respiratory Distress Syndrome in Very Preterm Infants: A Collaborative Study of 53 Multi-Center Trials in Korea / Journal of Korean Medical Science 29(8):1126~1131
Miedema M / 2011 / Changes in lung volume and ventilation during surfactant treatment in ventilated preterm infants / Am J Respir Crit Care Med 184:100~105
Fujiwara T / 1980 / Artificial surfactant therapy in hyaline-membrane disease / Lancet 1:55~59
Soll R / 2009 / Multiple versus single doses of exogenous surfactant for the prevention or treatment of neonatal respiratory distress syndrome / Cochrane Database Syst Rev (1):CD000141
김성미 / 2014 / Early Prophylactic versus Late Selective Use of Surfactant for Respiratory Distress Syndrome in Very Preterm Infants: A Collaborative Study of 53 Multi-Center Trials in Korea / Journal of Korean Medical Science 29(8):1126~1131
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