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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 111 - 117 (7page)
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초록· 키워드
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Purpose: Patent ductus arteriosus (PDA) is associated with increased mortality and morbidities such as intraventricular hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, and neurodevelopmental impairment. The objective of this study was to evaluate mortality and morbidities according to the time of PDA closure. Methods: For this study, 117 preterm infants with gestational age (GA) of <30 weeks who had PDA were enrolled and allocated to two groups according to the time of PDA closure as follows: early closed group (n=40, PDA closure in <14 days after birth) and delayed closed group (n=77, PDA closure in ≥14 days after birth). Results: GA was higher in the early closed group than in the delayed closed group (27.2±1.6 weeks vs. 26.3±1.7 weeks, P=0.005). Other demographic factors, such as birth weight, Apgar score, and maternal status were not significantly different between the two groups. The incidence rates of surfactant redosing, retinopathy of prematurity (stage ≥II), necrotizing enterocolitis (stage ≥II), moderate to severe bronchopulmonary dysplasia, and mortality were similar between the two groups. The total durations of mechanical ventilation, invasive ventilation, and hospital stay were longer in the delayed closed group than in the early closed group. However, these became similar after adjustment for GA. The incidence rate of intraventricular hemorrhage (grade ≥III) was significantly higher in the early closed group than in the delayed closed group after adjustment for GA (25.0% vs. 13.0%, adjusted P for GA=0.021). Conclusion: In this study, delayed PDA closure was safe, as it did not increase mortality and morbidity rates.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Wyllie JP / 2018 / Prophylactic and early targeted treatment of patent ductus arteriosus / Semin Fetal Neonatal Med 23:250~254
Liu H / 2008 / Expression, activity, and function of phosphodiesterases in the mature and immature ductus arteriosus / Pediatr Res 64:477~481
Vettukattil JJ / 2016 / Pathophysiology of patent ductus arteriosus in the preterm infant / Curr Pediatr Rev 12:120~122
Clyman RI / 2018 / Patent ductus arteriosus, its treatments, and the risks of pulmonary morbidity / Semin Perinatol 42:235~242
Finlay ER / 2000 / Pulmonary haemorrhage in preterm infants / Eur J Pediatr 159:870~871
Liu H / 2008 / Expression, activity, and function of phosphodiesterases in the mature and immature ductus arteriosus / Pediatr Res 64:477~481
Vettukattil JJ / 2016 / Pathophysiology of patent ductus arteriosus in the preterm infant / Curr Pediatr Rev 12:120~122
Clyman RI / 2018 / Patent ductus arteriosus, its treatments, and the risks of pulmonary morbidity / Semin Perinatol 42:235~242
Finlay ER / 2000 / Pulmonary haemorrhage in preterm infants / Eur J Pediatr 159:870~871
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Evaluation of echocardiographic markers in dogs with patent ductus arteriosus after ductal closure
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A Case of Ibuprofen Induced Transient Platelet Dysfunction in Preterm Infant
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Comparison Between Sodium Acetate and Sodium Chloride in Parenteral Nutrition for Very Preterm Infants on the Acid-Base Status and Neonatal Outcomes
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