지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 358 - 364 (7page)
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Purpose: The objective was to determine the characteristics and prognostic factors of 86 Chinese patients with trisomy 8 aberrationsand compare the prognostic value of International Prognostic System (IPSS) and Revised IPSS (IPSS-R) in this cohort.
Materials and Methods: A total of 86 cases diagnosed with primary myelodysplastic syndromes (MDS) with isolated tr8 or with tr8 and other additional cytogenetic aberrations diagnosed and treated at the Union Hospital, Tongji Medical College of Huazhong University of Science and Technology between July 2002 and March 2013 were reviewed.
Results: The median survival of the entire group was 23.0 months, and acute myeloid leukemia (AML) developed in 43% (37/86) patients within the follow up time. The univariate analysis revealed that overall survival (OS) was correlated with age, thrombocytopenia,absolute neutrophil count, marrow blasts, cytogenetic status and red blood cell transfusion at diagnosis, and the multivariateanalysis revealed that age, marrow blasts, cytogenetic status and transfusion dependence were independent parameters for the OS. The cytogenetic complexity and marrow blasts had the strongest impact on the AML transformation by multivariate analysis. Comparing the two prognostic systems, both two systems could successfully discriminate risk groups for survival. IPSS-R was more refined than IPSS for predicting OS, but had no advantage in predicting the risk of AML development.
Conclusion: This study confirmed the influence of clinical factors on the prognosis of 86 Chinese MDS patients with trisomy 8. In addition, IPSS-R can further refine prognostic discrimination in the IPSS risk categories.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Greenberg PL / 2002 / Myelodysplastic syndromes / Hematology Am Soc Hematol Educ Program 2002:136~161
Nimer SD / 2008 / Myelodysplastic syndromes / Blood 111:4841~4851
Nolte F / 2008 / Myelodysplastic syndromes: molecular pathogenesis and genomic changes / Ann Hematol 87:777~795
Mufti GJ / 2008 / Diagnosis and classification of myelodysplastic syndrome: International Working Group on Morphology of myelodysplastic syndrome (IWGM-MDS) consensus proposals for the definition and enumeration of myeloblasts and ring sideroblasts / Haematologica 93:1712~1717
Solé F / 2005 / Identification of novel cytogenetic markers with prognostic significance in a series of 968 patients with primary myelodysplastic syndromes / Haematologica 90:1168~1178
Nimer SD / 2008 / Myelodysplastic syndromes / Blood 111:4841~4851
Nolte F / 2008 / Myelodysplastic syndromes: molecular pathogenesis and genomic changes / Ann Hematol 87:777~795
Mufti GJ / 2008 / Diagnosis and classification of myelodysplastic syndrome: International Working Group on Morphology of myelodysplastic syndrome (IWGM-MDS) consensus proposals for the definition and enumeration of myeloblasts and ring sideroblasts / Haematologica 93:1712~1717
Solé F / 2005 / Identification of novel cytogenetic markers with prognostic significance in a series of 968 patients with primary myelodysplastic syndromes / Haematologica 90:1168~1178
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