지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 310 - 316 (7page)
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초록· 키워드
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Purpose: Infarct core can expand rapidly in acute stroke patients receiving intravenous tissue plasminogen activator (IV t-PA). We investigated changes in the extent of infarct core during IV t-PA treatment, and explored the associative factors of this infarct core expansion in patients with proximal artery occlusion. Materials and Methods: We included patients who were considered for sequential intra-arterial therapy (IAT) due to occlusion of intracranial proximal artery after IV t-PA. Patients who had a baseline Alberta Stroke Program Early Computed Tomography (CT) Score (ASPECTS) ≥6 and who underwent two consecutive CT scans before and shortly after IV t-PA infusion were enrolled. Patientswere classified into no, moderate, and marked expansion groups based on decreases in ASPECTS (0-1, 2-3, and ≥4, respectively)on follow-up CT. Collateral status was graded using CT angiography. Results: Of the 104 patients, 16 (15.4%) patients showed moderate and 13 (12.5%) patients showed marked infarct core expansion on follow-up CT scans obtained at 71.1±19.1 min after baseline CT scan. Sixteen (15.4%) patients had an ASPECTS value <6 on the follow-up CT. None of the patients with marked expansion were independent at 3 months. Univariate analysis and ordinal logisticregression analysis demonstrated that the infarct core expansion was significantly associated with collateral status (p<0.001). Conclusion: Among patients who were considered for IAT after IV t-PA treatment, one out of every seven patients exhibited marked expansion of infarct core on follow-up CT before IAT. These patients tend to have poor collaterals and poor outcomes despiterescue IAT.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Badhiwala JH / 2015 / Endovascular thrombectomy for acute ischemic stroke: a meta-analysis / JAMA 314:1832~1843
Berkhemer OA / 2015 / A randomized trial of intraarterial treatment for acute ischemic stroke / N Engl J Med 372:11~20
Campbell BC / 2015 / Endovascular therapy for ischemic stroke with perfusionimaging selection / N Engl J Med 372:1009~1018
Goyal M / 2015 / Randomized assessment of rapid endovascular treatment of ischemic stroke / N Engl J Med 372:1019~1030
Jovin TG / 2015 / Thrombectomy within 8 hours after symptom onset in ischemic stroke / N Engl J Med 372:2296~2306
Berkhemer OA / 2015 / A randomized trial of intraarterial treatment for acute ischemic stroke / N Engl J Med 372:11~20
Campbell BC / 2015 / Endovascular therapy for ischemic stroke with perfusionimaging selection / N Engl J Med 372:1009~1018
Goyal M / 2015 / Randomized assessment of rapid endovascular treatment of ischemic stroke / N Engl J Med 372:1019~1030
Jovin TG / 2015 / Thrombectomy within 8 hours after symptom onset in ischemic stroke / N Engl J Med 372:2296~2306
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