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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background and Purpose Rapid recanalization might improve clinical outcomes after intraarterial thrombolysis (IAT) for acute ischemic stroke patients with collateral circulation. We determined whether rapid recanalization and collateral circulation affect clinical outcomes after IAT.
Methods We retrospectively evaluated the clinical and radiological data of 134 consecutive patients who underwent IAT for intracranial artery occlusion. The interval from symptom onset to recanalization after IAT (onset-to-recanalization time) as an estimate of the probability of good clinical outcome (modified Rankin scale 0-2) was calculated in patients with collateral circulation in the ischemic hemisphere, which was rated poor (0/1 American Society of Interventional and Therapeutic Neuroradiology criteria) or good (2-4). Changes in National Institute of Health Stroke Scale (NHISS) score before and after IAT and modified Rankins scale scores 3 months after discharge were compared with respect to onset-to-recanalization time.
Results In patients with good collateral circulation, the estimated onset-to-recanalization time for a 0.5 probability of a good clinical outcome was 347 minutes; with poor collateral circulation, it was 172 minutes for a 0.2 probability of good clinical outcome. Outcome analyses according to onset-to-recanalization time showed patients recanalized <6 hours had lower NHISS scores (<4.5, 4.5-6, >6 hours of onset-to-recanalization time, and non-recanalization: 5.1, 6.9, 11.9, and 19.8, respectively) at discharge and higher percentages of good clinical outcome (69%, 66.7%, 21.9%, and 0%, respectively) 3 months after IAT.
Conclusions The time window to expect a high probability of a good clinical outcome after IAT is highly dependent on the collateral circulation.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Bang OY / 2008 / Impact of collateral flow on tissue fate in acute ischaemic stroke / J Neurol Neurosurg Psychiatry 79 : 625 ~ 629
Broderick JP / 2013 / Endovascular therapy after intravenous t-PA versus t-PA alone for stroke / N Engl J Med 368 : 893 ~ 903
Brott T / 1989 / Measurements of acute cerebral infarction: a clinical examination scale / Stroke 20 : 864 ~ 870
Castano C / 2010 / Mechanical thrombectomy with the Solitaire AB device in large artery occlusions of the anterior circulation:a pilot study / Stroke 41 : 1836 ~ 1840
Christoforidis GA / 2005 / Angiographic assessment of pial collaterals as a prognostic indicator following intra-arterial thrombolysis for acute ischemic stroke / Am J Neuro
Broderick JP / 2013 / Endovascular therapy after intravenous t-PA versus t-PA alone for stroke / N Engl J Med 368 : 893 ~ 903
Brott T / 1989 / Measurements of acute cerebral infarction: a clinical examination scale / Stroke 20 : 864 ~ 870
Castano C / 2010 / Mechanical thrombectomy with the Solitaire AB device in large artery occlusions of the anterior circulation:a pilot study / Stroke 41 : 1836 ~ 1840
Christoforidis GA / 2005 / Angiographic assessment of pial collaterals as a prognostic indicator following intra-arterial thrombolysis for acute ischemic stroke / Am J Neuro
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