지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 580 - 587 (8page)
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초록· 키워드
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Purpose: Androgen deprivation therapy (ADT) is used as a salvage treatment for men with biochemical recurrence (BCR) ofprostate cancer (PCa) following initial radical prostatectomy (RP). The optimal time at which to begin salvage ADT (sADT) remainscontroversial. In this retrospective study, we evaluated the efficacy of initiating sADT in patients before prostate-specificantigen (PSA) values met the clinical definition of BCR. Materials and Methods: We identified 484 PCa patients who received sADT for BCR after RP. Median follow-up was 82 months. Propensity score matching was performed based on preoperative PSA level, pathologic T stage, and Gleason score. Patients wereassigned to two groups of 169 patients each, based on PSA levels at the time of sADT: Group A (without meeting of the definitionof BCR) and Group B (after BCR). Kaplan-Meier survival analyses and Cox regression analyses were performed. Results: The median PSA level at sADT initiation was 0.12 ng/mL in group A and 0.42 ng/mL in group B. Kaplan-Meier analysesshowed that group A had favorable disease progression-free survival (DPFS) and distant metastasis-free survival (DMFS), but didnot have better cancer-specific survival (CSS) than group B. In subgroup analyses, group A showed better CSS rates in the nonorganconfined PCa group. In Cox regression analyses, early sADT was associated significantly with DPFS and DMFS rates, however,did not correlate with CSS (p=0.107). Conclusion: Early sADT after RP improved DPFS and DMFS. Furthermore, early sADT patients demonstrated better CSS in nonorganconfined PCa.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Siegel RL / 2017 / Cancer Statistics, 2017 / CA Cancer J Clin 67:7~30
Resnick MI / 1984 / Hormonal therapy in prostatic carcinoma / Urology 24(5 Suppl):18~23
Huggins C / 1942 / Effect of orchiectomy and irradiation on cancer of the prostate / Ann Surg 115:1192~1200
National Comprehensive Cancer Network / 2017 / National Comprehensive Cancer Network clinical practice guidelines in oncology ($NCCN^{(R)}$ ): prostate cancer. ver. 2 / National Comprehensive Cancer Network Inc
Bolla M / 2002 / Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial / Lancet 360:103~106
Resnick MI / 1984 / Hormonal therapy in prostatic carcinoma / Urology 24(5 Suppl):18~23
Huggins C / 1942 / Effect of orchiectomy and irradiation on cancer of the prostate / Ann Surg 115:1192~1200
National Comprehensive Cancer Network / 2017 / National Comprehensive Cancer Network clinical practice guidelines in oncology (
Bolla M / 2002 / Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial / Lancet 360:103~106
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