지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 98 - 102 (5page)
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초록· 키워드
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Purpose: To investigate the effects of early administration of dutasteride in patients with detectable serum prostate-specific antigen (PSA) levels after radical prostatectomy (RP). Materials and Methods: A prospective open-label study, with a cumulative analysis of asymptomatic increase in PSA following RP, was conducted from January 2005 to December 2013. An early increase in PSA level was defined as detectable serum PSA level> 0.04 ng/mL. Patients with PSA level>0.04 ng/mL were treated with dutasteride 0.5 mg daily. Serum PSA level and biochemical recurrence (BCR) were monitored. We divided the patients into 2 groups based on the serum PSA response after dutasteride treatment. Results: Eighty patients were included in the study. At the median follow-up of 51.8 months, 56 patients (70.0%) showed a decrease of greater than 10% in serum PSA level, and 24 showed increased PSA levels. Twelve of the 56 patients with PSA response showed subsequently increased PSA. Intergroup differences in preoperative PSA levels, PSA nadir levels, and Gleason score of 6 or less were significant (p=0.028, p=0.030, and p=0.035, respectively). A multivariate analysis revealed that Gleason score of 6 or less (p=0.018) and PSA nadir levels (p=0.011) were predictive factors for PSA response after early dutasteride treatment in men with increased PSA levels following RP. Conclusions: Early monotherapy of dutasteride showed a decline in serum PSA levels in men with lower nadir PSA levels, and a Gleason score 6, when the serum PSA was detected after RP.
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참고문헌 (17)
참고문헌 신청
Center MM / 2012 / International variation in prostate cancer incidence and mortality rates / Eur Urol 61:1079~1092
Zaorsky NG / 2013 / The dilemma of a rising prostate-specific antigen level after local therapy:what are our options? / Semin Oncol 40:322~336
Arai Y / 1998 / Ultrasensitive assay of prostate-specific antigen for early detection of residual cancer after radical prostatectomy / Int J Urol 5:550~555
Djavan B / 2003 / PSA progression following radical prostatectomy and radiation therapy:new standards in the new Millennium / Eur Urol 43:12~27
Marks LS / 2006 / The interpretation of serum prostate specific antigen in men receiving 5alpha-reductase inhibitors: a review and clinical recommendations / J Urol 176:868~874
Zaorsky NG / 2013 / The dilemma of a rising prostate-specific antigen level after local therapy:what are our options? / Semin Oncol 40:322~336
Arai Y / 1998 / Ultrasensitive assay of prostate-specific antigen for early detection of residual cancer after radical prostatectomy / Int J Urol 5:550~555
Djavan B / 2003 / PSA progression following radical prostatectomy and radiation therapy:new standards in the new Millennium / Eur Urol 43:12~27
Marks LS / 2006 / The interpretation of serum prostate specific antigen in men receiving 5alpha-reductase inhibitors: a review and clinical recommendations / J Urol 176:868~874
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