지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 167 - 180 (14page)
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초록· 키워드
오류제보하기
Purpose The purpose of this study was to investigate the clinical outcomes of postoperative radiotherapy (PORT) patients who underwent radical prostatectomy for localized prostate cancer. Materials and Methods Localized prostate cancer patients who received PORT after radical prostatectomy between 2001 and 2012 were identified retrospectively in a multi-institutional database. In total, 1,117 patients in 19 institutions were included. Biochemical failure after PORT was defined as prostate-specific antigen (PSA) ! nadir+2 after PORT or initiation of androgen deprivation therapy (ADT) for increasing PSA regardless of its value. Results Ten-year biochemical failure-free survival, clinical failure-free survival, distant metastasisfree survival, overall survival (OS), and cause-specific survival were 60.5%, 76.2%, 84.4%, 91.1%, and 96.6%, respectively, at a median of 84 months after PORT. Pre-PORT PSA " 0.5 ng/ml and Gleason’s score " 7 predicted favorable clinical outcomes, with 10-year OS rates of 92.5% and 94.1%, respectively. The 10-year OS rate was 82.7% for patients with a PSA > 1.0 ng/mL and 86.0% for patients with a Gleason score of 8-10. The addition of longterm ADT (! 12 months) to PORT improved OS, particularly in those with a Gleason score of 8-10 or ! T3b. Conclusion Clinical outcomes of PORT in a Korean prostate cancer population were very similar to those in Western countries. Lower Gleason score and serum PSA level at the time of PORT were significantly associated with favorable outcomes. Addition of long-term ADT (! 12 months) to PORT should be considered, particularly in unfavorable risk patients with Gleason scores of 8-10 or ! T3b.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Roehl KA / 2004 / Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3, 478 consecutive patients : long-term results / J Urol 172:910~914
Pound CR / 1999 / Natural history of progression after PSA elevation following radical prostatectomy / JAMA 281:1591~1597
Trock BJ / 2008 / Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy / JAMA 299:2760~2769
Cotter SE / 2011 / Salvage radiation in men after prostate-specific antigen failure and the risk of death / Cancer 117:3925~3932
Bolla M / 2012 / Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer : long-term results of a randomised controlled trial(EORTC trial 22911) / Lancet 380:2018~2027
Pound CR / 1999 / Natural history of progression after PSA elevation following radical prostatectomy / JAMA 281:1591~1597
Trock BJ / 2008 / Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy / JAMA 299:2760~2769
Cotter SE / 2011 / Salvage radiation in men after prostate-specific antigen failure and the risk of death / Cancer 117:3925~3932
Bolla M / 2012 / Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer : long-term results of a randomised controlled trial(EORTC trial 22911) / Lancet 380:2018~2027
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