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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 840 - 845 (6page)
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Purpose: To evaluate the prognosis of nasopharyngeal carcinoma (NPC) patients who developed bone-only metastasis after primarytreatment and the stratification of these patients into different risk groups based on independent prognostic factors.
Materials and Methods: Eighty NPC patients who developed bone-only metastasis after definitive radiotherapy from October 2005to December 2010 were enrolled. All these patients received palliative treatment for bone metastasis, including chemotherapyand/or radiotherapy. Clinical features, treatment modality, and laboratory parameters were examined with univariate and multivariateanalyses.
Results: The median follow-up time was 15.5 months (range, 2–67 months) for the whole cohort. The median overall metastaticsurvival (OMS) time and the 2-year estimate OMS rate were 26.5 months and 52%, respectively. Multivariate analysis indicated thatpatients with short metastases-free interval, multiple bone metastases sites, high serum lactic dehydrogenase levels, and treatedwith radiotherapy or chemotherapy alone had significantly worse outcomes. Patients were stratified into three different risk groupsbased on the number of adverse factors present. The OMS curves of the three groups were all significantly different (p<0.001).
Conclusion: Severl prognostic factors were found to be associated with worse outcomes. According to the number of adverse factorspresent, bone-only metastasis patients can be stratified into three risk groups with significantly different prognoses. Suchgrouping may help in improving the design of clinical trials and in guiding individualized treatment for NPC patients with boneonlymetastasis.
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참고문헌 (26)
참고문헌 신청
Wei WI / 2005 / Nasopharyngeal carcinoma / Lancet 365:2041~2054
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
Lai SZ / 2011 / How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? / Int J Radiat Oncol Biol Phys 80:661~668
Peng G / 2012 / A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma / Radiother Oncol 104:286~293
Lin S / 2014 / Update report of nasopharyngeal carcinoma treated with reduced-volume intensitymodulated radiation therapy and hypothesis of the optimal margin / Radiother Oncol 110:385~389
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
Lai SZ / 2011 / How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? / Int J Radiat Oncol Biol Phys 80:661~668
Peng G / 2012 / A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma / Radiother Oncol 104:286~293
Lin S / 2014 / Update report of nasopharyngeal carcinoma treated with reduced-volume intensitymodulated radiation therapy and hypothesis of the optimal margin / Radiother Oncol 110:385~389
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