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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 912 - 922 (11page)
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초록· 키워드
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Stereotactic body radiotherapy (SBRT) is a form of radiotherapy that delivers high doses of irradiation with high precision in a small number of fractions. However, it has not frequently been performed for the liver due to the risk of radiation-induced liver toxicity. Furthermore, liver SBRT is cumbersome because it requires accurate patient repositioning, target localization, control of breathing-related motion, and confers a toxicity risk to the small bowel. Recently, with the advancement of modern technologies including intensity-modulated RT and image-guided RT, SBRT has been shown to significantly improve local control and survival outcomes for hepatocellular carcinoma (HCC), specifically those unfit for other local therapies. While it can be used as a stand-alone treatment for those patients, it can also be applied either as an alternative or as an adjunct to other HCC therapies (e.g., transarterial chemoembolization, and radiofrequency ablation). SBRT might be an effective and safe bridging therapy for patientsawaiting liver transplantation. Furthermore, in recent studies, SBRT has been shown to have a potential role as an immunostimulator,supporting the novel combination strategy of immunoradiotherapy for HCC. In this review, the role of SBRT with some technical issues is discussed. In addition, future implications of SBRT as an immunostimulator are considered.
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참고문헌 (74)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
El-Serag HB / 2007 / Hepatocellular carcinoma: epidemiology and molecular carcinogenesis / Gastroenterology 132:2557~2576
Potters L / 2004 / American Society for Therapeutic Radiology and Oncology and American College of Radiology practice guideline for the performance of stereotactic body radiation therapy / Int J Radiat Oncol Biol Phys 60:1026~1032
Blomgren H / 1995 / Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients / Acta Oncol 34:861~870
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90
El-Serag HB / 2007 / Hepatocellular carcinoma: epidemiology and molecular carcinogenesis / Gastroenterology 132:2557~2576
Potters L / 2004 / American Society for Therapeutic Radiology and Oncology and American College of Radiology practice guideline for the performance of stereotactic body radiation therapy / Int J Radiat Oncol Biol Phys 60:1026~1032
Blomgren H / 1995 / Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients / Acta Oncol 34:861~870
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Long-term complete response after transcatheter arterial chemoembolization and stereotactic body radiation therapy in a patient with hepatocellular carcinoma at the caudate lobe
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Pre-clinical study of Combination of Oncothermia with SBRT and Metformin in vivo
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Stereotactic body radiation therapy for liver oligo-recurrence and oligo-progression from various tumors
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Strategic application of radiotherapy for hepatocellular carcinoma
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Current role of proton beam therapy in patients with hepatocellular carcinoma
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