지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: To retrospectively assess whether the response of subtrochanteric lateral cortex (STLC) is different according to the bisphosphonate agents in terms of bone mineral density (BMD) change. Methods: A total of 149 subjects, who had 2- to 4-year interval follow-up of BMD using dual energy X-ray absorptiometry (DXA), were included in this retrospective study divided into following 3 groups: control group (no consumption of any anti-osteoporotic drugs, n=38), alendronate group (naïve alendronate users, n=48), risedronate group (naïve risedronate users, n=63). BMD was measured at the STLC and subtrochanteric medial cortex (STMC) in each patient by drawing rectangular ROIs at the bone cortices. The percent change of BMD at the STLC were compared between the aforementioned 3 groups by using analysis of covariance model to control five independent variables of age, body mass index, percent change of STMC, hip axis length, time interval between DXA examinations. Results: The least square mean values±standard deviation of the percent change of BMD in the control, alendronate, and risedronate groups were 1.46±1.50, 2.23±1.26, and 6.96±1.11, respectively. The risedronate group showed significantly higher change of BMD percentage compared with the control (adjusted P=0.012) or alendronate (adjusted P=0.016) groups. Conclusions: The percent change of BMD at the STLC in the risedronate user group was greater than the alendronate and control groups. The implication of these changes needs to be further verified.
목차
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참고문헌 (29)
참고문헌 신청
Bone HG / 2004 / Ten years' experience with alendronate for osteoporosis in postmenopausal women / N Engl J Med 350:1189~1199
Dell RM / 2012 / Incidence of atypical nontraumatic diaphyseal fractures of the femur / J Bone Miner Res 27:2544~2550
Goh SK / 2007 / Subtrochanteric insufficiency fractures in patients on alendronate therapy : a caution / J Bone Joint Surg Br 89:349~353
Lee YK / 2013 / Bisphosphonate use and increased incidence of subtrochanteric fracture in South Korea : results from the National Claim Registry / Osteoporos Int 24:707~711
Meier RP / 2012 / Increasing occurrence of atypical femoral fractures associated with bisphosphonate use / Arch Intern Med 172:930~936
Dell RM / 2012 / Incidence of atypical nontraumatic diaphyseal fractures of the femur / J Bone Miner Res 27:2544~2550
Goh SK / 2007 / Subtrochanteric insufficiency fractures in patients on alendronate therapy : a caution / J Bone Joint Surg Br 89:349~353
Lee YK / 2013 / Bisphosphonate use and increased incidence of subtrochanteric fracture in South Korea : results from the National Claim Registry / Osteoporos Int 24:707~711
Meier RP / 2012 / Increasing occurrence of atypical femoral fractures associated with bisphosphonate use / Arch Intern Med 172:930~936
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