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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives: To evaluate and compare the efficacy and safety of the combination of raloxifene and alendronate with those ofmonotherapies in elderly women with osteoporosis.
Methods: Sixty-two postmenopausal women (mean age 63.5 ± 0.5 years) attending gynecologic osteoporosis clinics withestablished osteoporosis were randomly allocated to one of four treatment groups and monitored for 3 years. All patients enrolledin this study, including those in the control group (n = 14), received 1.0 g elemental calcium and 400 units of vitamin D per day.
The raloxifene group (n = 16) received raloxifene 60 mg (Evista®) per day; alendronate group (n = 17) received low-dose (5 mg)alendronate with calcitriol 0.5 μg (Maxmarvil®) per day; and the combination therapy group (n = 15) received both raloxifene 60mg and low-dose (5 mg) alendronate with calcitriol 0.5 μg. Bone mineral density (BMD) was measured in the lumbar spine and hipbefore and after 3 years of treatment.
Results: In patients who received the combined therapy, BMD increased in the lumbar spine and the hip by 7.2% (P < 0.001)and 4.8% (P < 0.001) at 3 years. For patients in the alendronate group, the increases were 6.7% (P < 0.001) and 3.1% (P < 0.01)respectively, for the raloxifene group, the increases were 4.36% (P < 0.001) and 1.9% (P < 0.05) in the vertebrae and femora,respectively; however, the BMD of patients in the control group decreased by 1.81% (P < 0.05) and 1.6% (P < 0.05), respectively,after 3 years. Patients who received the combination therapy had significantly higher BMD in both the vertebrae femora (P < 0.01)in comparison to that in those treated with raloxifene or alendronate individually.
Conclusions: This 3-year randomized study showed the improved effects of alendronate and raloxifene combination on spine andhip BMD in elderly postmenopausal women with established osteoporosis. (J Menopausal Med 2017;23:56-62)
목차
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참고문헌 (23)
참고문헌 신청
Anonymous / 2000 / NIH consensus declares osteoporosis a major public health issue / Osteoporos Rep 16 : 1 ~
Bone HG / 2000 / Alendronate and estrogen effects in postmenopausal women with low bone mineral density / J Clin Endocrinol Metab 85 : 720 ~ 726
Cummings SR / 2002 / Epidemiology and outcomes of osteoporotic fractures / Lancet 359 : 1761 ~ 1767
Cummings SR / 2002 / Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs / Am J Med 112 : 281 ~ 289
Delmas PD / 2002 / Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis:four-year results from a randomized clinical trial /
Bone HG / 2000 / Alendronate and estrogen effects in postmenopausal women with low bone mineral density / J Clin Endocrinol Metab 85 : 720 ~ 726
Cummings SR / 2002 / Epidemiology and outcomes of osteoporotic fractures / Lancet 359 : 1761 ~ 1767
Cummings SR / 2002 / Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs / Am J Med 112 : 281 ~ 289
Delmas PD / 2002 / Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis:four-year results from a randomized clinical trial /
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