지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Background: The efficacy of bisphosphonates for osteoporotic fracture has been consistently reported in recent randomized controlled trials (RCTs) enrolling hundreds of patients. The objective of this study was to update knowledge on the efficacy of available bisphosphonates in the prevention of vertebral and non-vertebral fractures. Methods: An approach “using systematic reviews” on PubMed and Cochrane Library was taken.
Twenty-four RCTs investigating the effects of bisphosphonates for the prevention of osteoporotic fracture were included in final analysis. A pairwise meta-analysis was conducted with a random effects model. Subgroup analysis was performed according to the type of bisphosphonate. Results: The use of bisphosphonate decrease the risk of overall osteoporotic fracture (odds ratio [OR] 0.62; P<0.001), vertebral fracture (OR 0.55; P<0.001) and non-vertebral fracture (OR 0.73; P<0.001). Subgroup analysis indicated that zoledronic acid showed the lowest risk reduction (OR 0.61; P<0.001) for overall osteoporotic fractures but no significance was observed for etidronate (OR 0.34; P=0.127).
Conclusions: This update meta-analysis re-confirmed that bisphosphonate use can effectively reduce the risk of osteoporotic fracture. However, there is a lack of evidence regarding etidronate for the prevention of osteoporotic fracture.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bai H / 2013 / Randomized controlled trial of zoledronic acid for treatment of osteoporosis in women / J Int Med Res 41 : 697 ~ 704
Bilezikian JP / 2009 / Efficacy of bisphosphonates in reducing fracture risk in postmenopausal osteoporosis / Am J Med 122 : S14 ~ S21
Black DM / 1996 / Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group / Lanc
Boonen S / 2009 / Once-weekly risedronate in men with osteoporosis: results of a 2-year, placebo-controlled, double-blind, multicenter study / J Bone Miner Res 24 : 719 ~ 72
Boonen S / 2012 / Fracture risk and zoledronic acid therapy in men with osteoporosis / N Engl J Med 367 : 1714 ~ 1723
Bilezikian JP / 2009 / Efficacy of bisphosphonates in reducing fracture risk in postmenopausal osteoporosis / Am J Med 122 : S14 ~ S21
Black DM / 1996 / Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group / Lanc
Boonen S / 2009 / Once-weekly risedronate in men with osteoporosis: results of a 2-year, placebo-controlled, double-blind, multicenter study / J Bone Miner Res 24 : 719 ~ 72
Boonen S / 2012 / Fracture risk and zoledronic acid therapy in men with osteoporosis / N Engl J Med 367 : 1714 ~ 1723
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