지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: The purpose of this prospective, open-label, observational study was to assess the fracture preventing effect of Maxmarvil® tablets (alendronate 5 mg + calcitriol 0.5 μg) in patients with osteoporosis and to evaluate the change in bone mineral density (BMD) at the minimum 1-year follow-up. Methods: In this multicenter observational study, 691 patients with osteoporosis (aged 50 years or older) were treated with alendronate 5 mg + calcitriol 0.5 μg/day during their normal course of care. Patients were assessed at baseline and at 6 and 12 months. Baseline characteristics (including age, gender, concomitant disease, and baseline fractures) were evaluated. Results: From among the 848 participants, 149 individuals were lost to follow-up at the time of the study and 8 people had died. The 691 participants (54 men and 637 women) finished the follow-up study and completed the questionnaire. The mean age of the participants was 71.5 years (range, 50-92 years; mean age, 72.3 years for men and 71.4 years for women). Osteoporotic fracture occurred in 19 patients (2.7%). BMD of the lumbar spine and hip was improved by 5% and 1.5% at the latest follow-up. At the latest follow-up, 24 patients (3.5%) complained of drug-related complications such as dyspepsia, constipation, and nausea. Conclusions: This prospective observational study demonstrated that alendronate 5 mg + calcitriol 0.5 μg/day had a preventive effect on osteoporotic fracture and it increased the BMD of the lumbar spine by 5% at the latest follow-up.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Abimanyi-Ochom J / 2015 / Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractur
Bonnick S / 2006 / Comparison of weekly treatment of postmenopausal osteoporosis with alendronate versus risedronate over two years / J Clin Endocrinol Metab 91 : 2631 ~ 263
Center JR / 2011 / Osteoporosis medication and reduced mortality risk in elderly women and men / J Clin Endocrinol Metab 96 : 1006 ~ 1014
Cree MW / 2003 / Mortality and morbidity associated with osteoporosis drug treatment following hip fracture / Osteoporos Int 14 : 722 ~ 727
Foster SA / 2013 / Fractures in women treated with raloxifene or alendronate: a retrospective database analysis / BMC Womens Health 13 : 15 ~
Bonnick S / 2006 / Comparison of weekly treatment of postmenopausal osteoporosis with alendronate versus risedronate over two years / J Clin Endocrinol Metab 91 : 2631 ~ 263
Center JR / 2011 / Osteoporosis medication and reduced mortality risk in elderly women and men / J Clin Endocrinol Metab 96 : 1006 ~ 1014
Cree MW / 2003 / Mortality and morbidity associated with osteoporosis drug treatment following hip fracture / Osteoporos Int 14 : 722 ~ 727
Foster SA / 2013 / Fractures in women treated with raloxifene or alendronate: a retrospective database analysis / BMC Womens Health 13 : 15 ~
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