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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 304 - 313 (10page)
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초록· 키워드
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Background: Although the incidence of non-melanoma skin cancer is increasing, there are no effective practical preventive measures other than avoiding sun exposure.
Objective: To elucidate the protective effect of topical application of biologically active vitamin D3 (calcitriol) on skin cancer development caused by exposure to ultraviolet (UV).
Methods: Groups of hairless mice were topically treated with either calcitriol or vehicle immediately after exposure to UVB and UVA three times weekly for the initial 20 weeks, and without UV exposure in the following 6 weeks. Tumor number was counted and biopsies were done for histopathologic analysis. The changes of cyclobutane pyrimidine dimer (CPD) were evaluated 1 hour and 11 hours after short term of UV exposure and application of calcitriol. For safety evaluation, blood test and body weights were evaluated at 23rd and 25th week. Results: Total tumor count and number of tumors less than 3 mm in size tended to be fewer in calcitriol group, and tumors more than 3 mm in size showed significantly lower tumor formation rate in calcitriol group.
Single application of calcitriol reduced CPD at 1 hour and 11 hours after UV exposure. Histopathologic analysis showed tumors with lower grade malignancy in calcitriol group which suggested a delay in tumor progression. However, serum levels of calcium and phosphate in calcitriol group were above normal range, and weight loss was found. Conclusion: Topical calcitriol may suppress the formation and progression of UV-induced non-melanoma skin cancer by enhancing the repair mechanism of UV damage.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Bikle DD / 2010 / Vitamin D and the skin / J Bone Miner Metab 28:117~130
Rosen CJ. / 2012 / The nonskeletal effects of vitamin D : an endocrine society scientific statement / Endocr Rev 33:456~492
Hong SP. / 2008 / Biopositive effects of low-dose UVB on epidermis : coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement / J Invest Dermatol 128:2880~2887
Bikle DD / 2012 / Protective actions of vitamin D in UVB induced skin cancer / Photochem Photobiol Sci 11:1808~1816
Bikle DD. / 2013 / Protective role of vitamin D signaling in skin cancer formation / J Steroid Biochem Mol Biol 136:271~279
Rosen CJ. / 2012 / The nonskeletal effects of vitamin D : an endocrine society scientific statement / Endocr Rev 33:456~492
Hong SP. / 2008 / Biopositive effects of low-dose UVB on epidermis : coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement / J Invest Dermatol 128:2880~2887
Bikle DD / 2012 / Protective actions of vitamin D in UVB induced skin cancer / Photochem Photobiol Sci 11:1808~1816
Bikle DD. / 2013 / Protective role of vitamin D signaling in skin cancer formation / J Steroid Biochem Mol Biol 136:271~279
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