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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose : The Korean health insurance has covered the use of everolimus in adult patients receiving liver transplants with the concomitant use of both tacrolimus and corticosteroids since June 1st 2015. This study was conducted to analyze the use of everolimus in patients who have received a liver transplantation at the Samsung Medical Center. Methods : The secured electronic medical records of 105 patients, who took everolimus from June 1st 2015 to June 30th 2016, were retrospectively reviewed. We analyzed adherence to the recommended prescription as requried and noted and mesured the incidence of side effects. Results : Among the 105 patients, there were 103 patients (98.1%) who started everolimus treatment 4 weeks after having received their transplantation, and 62 (59.0%) started 0.5 mg/dose and 32 (30.5%) took 1 mg/dose of everolimus twice a day. The rate of maintaining the trough concentration of 3 to 8 ng/mL of everolimus was 53.0% within 1 month after the administration, 46.8% from 1 to 3 months, and 48.2% from 3 to 6 months. There were a number of patients whose serum levels were below the recommended range, but the recoded serum trough concentrations were continuously monitored and the incidence of a post-transplant rejection was low (1.9%). The blood analysis data showed more than 240 mg/dL of total cholesterol in 40 patients (38.1%) during the administration period. Conclusion : Further studies on the proper initial dose and maintenance of an adequate drug concentration ranges in the Korean population are needed. In addition, due to the increased risk of dyslipidemia after everolimus administration, the periodic monitoring of the blood lipid profiles is important and appropriate measures should be taken when necessary. Therefore, in order to contribute to effective drug use and minimize side effects, it requires a more proactive role of pharmacists in prescription monitoring and interventions with use of this therapy.
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참고문헌 (20)
참고문헌 신청
Saliba F / 2017 / Efficacy and safety of everolimus and mycophenolic acid with early tacrolimus withdrawal after liver transplantation: A multicenter, randomized trial / Am J Transplant 17(7):1843~1852
Lin M / 2017 / Everolimus with early withdrawal or reduced-dose calcineurin inhibitors improves renal function in liver transplant recipients: A systematic review and meta-analysis / Clinical Transplantation
Herden U / 2016 / Early initiation of everolimus after liver transplantation: A single-center experience / Annals of Transplantation 21:77~85
Lamattina JC / 2011 / Chronic kidney disease stage progression in liver transplant recipients / Clinical Journal of the American Society of Nephrology 6(8):1851~1857
Herzer K / 2016 / Selection and use of immunosuppressive therapies after liver transplantation: current German practice / Clin Transplant 30(5):487~501
Lin M / 2017 / Everolimus with early withdrawal or reduced-dose calcineurin inhibitors improves renal function in liver transplant recipients: A systematic review and meta-analysis / Clinical Transplantation
Herden U / 2016 / Early initiation of everolimus after liver transplantation: A single-center experience / Annals of Transplantation 21:77~85
Lamattina JC / 2011 / Chronic kidney disease stage progression in liver transplant recipients / Clinical Journal of the American Society of Nephrology 6(8):1851~1857
Herzer K / 2016 / Selection and use of immunosuppressive therapies after liver transplantation: current German practice / Clin Transplant 30(5):487~501
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Cross-sectional analysis of immunosuppressive regimens focused on everolimus after liver transplantation in a Korean high-volume transplantation center
Clinical Transplantation and Research
2019 .01
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Impact of Everolimus on Survival After Liver Transplantation for Hepatocellular Carcinoma
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Effect of everolimus rescue therapy for acute cellular rejection following pediatric living donor liver transplantation: Report of one case
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A systematic review and meta-analysis comparing everolimus and calcineurin inhibitors (CNIs) to mycophenolate and CNIs in kidney transplant patients
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2023 .03
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Effect of everolimus rescue therapy for acute cellular rejection following living donor liver transplantation: Report of one case
Annals of Hepato-Biliary-Pancreatic Surgery
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Early use of everolimus improved renal function after adult deceased donor liver transplantation
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Immunosuppressive Drug Measurement by Liquid Chromatography Coupled to Tandem Mass Spectrometry: Interlaboratory Comparison in the Korean Clinical Laboratories
Annals of Laboratory Medicine
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Limited antitumor effect of everolimus in an in vitro Hepg2 cell line study
한국간담췌외과학회 학술대회지
2016 .04
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An Unusual Case of Colon Perforation With Multiple Transmural Ulcers After Use of Polmacoxib and Everolimus in a Metastatic Breast Cancer Patient
Annals of Coloproctology
2021 .01
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Fibrous Plaque of the Eyelid in a Patient with Tuberous Sclerosis Responding to Everolimus
Annals of Dermatology
2018 .01
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실제 임상현장에서의 간이식 환자 대상 Everolimus와 저용량 Tacrolimus 병용요법의 유효성 및 안전성 평가
한국임상약학회지
2021 .01
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Crizotinib in Combination with Everolimus Synergistically Inhibits Proliferation of Anaplastic Lymphoma KinasePositive Anaplastic Large Cell Lymphoma
Cancer Research and Treatment
2018 .01
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Oral health management of a patient with tuberous sclerosis complex for oral mucositis under everolimus: A case report
International Journal of Disability and Oral Health
2020 .06
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A cross-sectional analysis of long-term immunosuppressive regimens after liver transplantation at Asan Medical Center : Increased preference for mycophenolate mofetil
Annals of Hepato-Biliary-Pancreatic Surgery
2018 .02
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Reduced restenosis and enhanced re-endothelialization of functional biodegradable vascular scaffolds by everolimus and magnesium hydroxide
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2023 .03
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Everolimus Plus Ku0063794 Regimen Promotes Anticancer Effects against Hepatocellular Carcinoma Cells through the Paradoxical Inhibition of Autophagy
Cancer Research and Treatment
2018 .01
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2017 .01
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Comparison of the Effectiveness and Clinical Outcome of Everolimus Followed by CDK4/6 Inhibitors with the Opposite Treatment Sequence in Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer
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