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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 98 - 105 (8page)
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초록· 키워드
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Background: The mammalian target of the rapamycin inhibitor has dual inhibitory effects on cell growth and angiogenesis. This study aimed to analyze the usage of everolimus on actual immunosuppression (IS) regimens through a cross-sectional study in a high-volume liver transplantation (LT) center. Methods: Our institutional LT database was searched for adult patients who underwent primary LT surgery between January 2010 and December 2016. We identified 2,093 LT recipients with observation periods of 1 to 8 years. Results: We divided the 2,093 recipients into three groups according to the posttransplant follow-up period as follows: group A (12–36 months; n=680), group B (37–60 months; n=560), and group C (＞60 months; n=853). The individual IS agents were tacrolimus in 1,807 patients (86.3%), cyclosporine in 169 patients (8.1%), mycophenolate mofetil (MMF) in 1,310 patients (62.6%), and everolimus in 115 patients (5.5%). The most common IS regimens were tacrolimus-MMF combination and tacrolimus monotherapy, regardless of the posttransplant period. Patients with pretransplant malignancies were administered everolimus more frequently than those without pretransplant malignancies (P＜0.001). In 102 patients with hepatocellular carcinoma recurrence or de novo malignancies, IS regimens included everolimus-tacrolimus in 41 patients (40.2%), tacrolimus-MMF in 27 patients (26.4%), tacrolimus in 20 patients (19.6%), MMF in 10 patients (9.8%), cyclosporine in three patients (2.9%), and cyclosporine-MMF in one patient (1.0%). Conclusions: Administration of everolimus after LT has been gradually increasing with the expansion of indications in our institutional practice. Currently, the role of everolimus is minimal and not comparable to that of tacrolimus, but it has a unique position in the field of IS after LT.
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참고문헌 (24)
참고문헌 신청
Kang SH / 2014 / Tailored long-term immunosuppressive regimen for adult liver transplant recipients with hepatocellular carcinoma / Korean J Hepatobiliary Pancreat Surg 18:48~51
Hwang S / 2010 / A clinical assessment of mycophenolate drug monitoring after liver transplantation / Clin Transplant 24:E35~E42
Hwang S / 2018 / A cross-sectional analysis of long-term immunosuppressive regimens after liver transplantation at Asan Medical Center: increased preference for mycophenolate mofetil / Ann Hepatobiliary Pancreat Surg 22:19~26
Clavien PA / 2012 / Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report / Lancet Oncol 13:e11~e22
Jung DH / 2018 / Antitumor effect of sorafenib and mammalian target of rapamycin inhibitor in liver transplantation recipients with hepatocellular carcinoma recurrence / Liver Transpl 24:932~945
Hwang S / 2010 / A clinical assessment of mycophenolate drug monitoring after liver transplantation / Clin Transplant 24:E35~E42
Hwang S / 2018 / A cross-sectional analysis of long-term immunosuppressive regimens after liver transplantation at Asan Medical Center: increased preference for mycophenolate mofetil / Ann Hepatobiliary Pancreat Surg 22:19~26
Clavien PA / 2012 / Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report / Lancet Oncol 13:e11~e22
Jung DH / 2018 / Antitumor effect of sorafenib and mammalian target of rapamycin inhibitor in liver transplantation recipients with hepatocellular carcinoma recurrence / Liver Transpl 24:932~945
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Crizotinib in Combination with Everolimus Synergistically Inhibits Proliferation of Anaplastic Lymphoma KinasePositive Anaplastic Large Cell Lymphoma
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Efficacy and safety of a switch from twice- daily tacrolimus to once-daily generic tacrolimus in stable liver transplant patients
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