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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 310 - 319 (10page)
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Myristoylated alanine-rich C kinase substrate (MARCKS) is a (PKC) substrate and has been implicated in actin cytoskeletal rearrangement in response to extra-cellular stimuli. Although MARCKS was extensively examined in various cell culture systems, the physiological function of MARCKS in the central nervous system has not been clearly understood. We investigated alterations of cellular distribution and phosphorylation of MARCKS in the hippocampus following kainic acid (KA)-induced seizures. KA (25 mg/kg, i.p.) was administered to eight to nine week-old C57BL/6 mice. Behavioral seizure activity was observed for 2 h after the onset of seizures and was terminated with diazepam (8 mg/kg, i.p.). The animals were sacrificed and analyzed at various points in time after the initiation of seizure activity. Using double-labeling immunofluorescence analy-phosphorylation of MARCKS was dramatically upregulated specifically in microglial cells after KA-induced seizures, but not in other types of glial cells. PKC α, β I, β II and δ, from various PKC isoforms examined, also were markedly upregulated, speci-fically in microglial cells. Moreover, immunore-activities of phosphorylated MARCKS were co- localized in the activated microglia with those of the above isoforms of PKC. Taken together, our in vivo data suggest that MARCKS is closely linked to microglial activation processes, which are important mation and neurodegeneration.
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참고문헌 (25)
참고문헌 신청
/ / Modification of seizure activity by electrical stimulation : 281 ~ 94
/ / The MARCKS family of cellular protein kinase C substrates : 1501 ~ 4
/ / a family of protein kinase C substrates : 713 ~ 6
/ 1990 / Localization of the MARCKS a major specific MARCKS expression in microglia 319substrate for protein kinase C : 87 1683 ~ 1698
/ 1995 / Protein kinase C regulates MARCKS cy-cling between the plasma membrane and lysosomes in fibroblasts. 14 : 1109 ~ 21
/ / The MARCKS family of cellular protein kinase C substrates : 1501 ~ 4
/ / a family of protein kinase C substrates : 713 ~ 6
/ 1990 / Localization of the MARCKS a major specific MARCKS expression in microglia 319substrate for protein kinase C : 87 1683 ~ 1698
/ 1995 / Protein kinase C regulates MARCKS cy-cling between the plasma membrane and lysosomes in fibroblasts. 14 : 1109 ~ 21
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