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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 533 - 545 (13page)
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초록· 키워드
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Kainic acid (KA) is well-known as an excitatory, neurotoxic substance. In mice, KA administered intracerebroventricularly (i.c.v.) lead to morpholo-gical damage of hippocampus expecially concent-rated on the CA3 pyramidal neurons. In the present study, the possible role of γ-aminobutyric acid B (GABAB) receptors in hippocampal cell death induced by KA (0.1 g) administered i.c.v. was examined. 5-Aminovaleric acid (5-AV; GABAB recep-tors antagonist, 20 g) reduced KA-induced CA3 pyramidal cell death. KA increased the phos-phorylated extracellular signal-regulated kinase (p-ERK) and Ca2+/calmodulin-dependent protein kinase II (p-CaMK II) immunoreactivities (IRs) 30 min after KA treatment, and c-Fos, c-Jun IR 2 h, and glial fibrillary acidic protein (GFAP), complement recep-KA-injected mice. 5-AV attenuated KA-induced p-CaMK II, GFAP and OX-42 IR in the hippocampal CA3 region. These results suggest that p-CaMK II may play as an important regulator on hippocampal cell death induced by KA administered i.c.v. in mice. Activated astrocytes, which was presented by GFAP IR, and activated microglia, which was presented by the OX-42 IR, may be a good indicator for measuring the cell death in hippocampal regions by KA excito-toxicity. Furthermore, it showed that GABAB recep-tors appear to be involved in hippocampal CA3 pyramidal cell death induced by KA administered i.c.v. in mice.
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참고문헌 (28)
참고문헌 신청
[학
Ault B / brjpharmacol1983 / Anticonvulsant-like actions of baclofen inthe rat hippocampal slice : 701 ~ 8
Baik EJ / 1999 / Cyclooxygenase-2selective inhibitors aggravate kainic acid induced seizureand neuronal cell death in the hippocampus 843 : 118 ~ 29
Baker H / neuroscience1993 / Olfactory afferent regulation of thedopamine phenotype in the fetal rat olfactory system 52 : 115 ~ 34
Ben-Ari Y / trendsneurosci2000 / a double agent that generatesseizures two decades of progress 23 : 580 ~ 7
Ault B / brjpharmacol1983 / Anticonvulsant-like actions of baclofen inthe rat hippocampal slice : 701 ~ 8
Baik EJ / 1999 / Cyclooxygenase-2selective inhibitors aggravate kainic acid induced seizureand neuronal cell death in the hippocampus 843 : 118 ~ 29
Baker H / neuroscience1993 / Olfactory afferent regulation of thedopamine phenotype in the fetal rat olfactory system 52 : 115 ~ 34
Ben-Ari Y / trendsneurosci2000 / a double agent that generatesseizures two decades of progress 23 : 580 ~ 7
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