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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 483 - 490 (8page)
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Skeletal muscle contains several precursor cells that generate muscle, bone, cartilage and blood cells. Although there are reports that skeletal muscle-derived cells can trans-diferentiate into neural-lineage cells, methods for isolating precursor cells, and procedures for successful neural induction have not been fuly established. Here, we show that the preplate cell iso-lation method, which separates cells based on their ad-hesion characteristics, permits separation of cells pos-sessing neural precursor characteristics from other cells of skeletal muscle tissues. We term these isolated cells skeletal muscle-derived neural precursor cells (SMNPs). The isolated SMNPs constitutively expressed neural stem cell markers. In addition, we describe effec-tive neural induction materials permiting the neu-ron-like cell diferentiation of SMNPs. Treatment with retinoic acid or forskolin facilitated morphological changes in SMNPs; they diferentiated into neuron-like cells that possessed specific neuronal markers. These results sugest that the preplate isolation method, and treatment with retinoic acid or forskolin, may provide vi-tal assistance in the use of SMNPs in cell-based therapy of neuronal disease.
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참고문헌 (29)
참고문헌 신청
Alessandri G / 2004 / Isolation and culture of human muscle-derived stem cells able to differentiate into myogenic and neurogenic cell lineages 364 ( ) : 1872 ~ 1883
Bonni A / 1997 / Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway 278 : 477 ~ 483
Cho JH / 2001 / Overexpression of BETA2/NeuroD induces neurite outgrowth in F11 neuroblastoma cells 77 : 103 ~ 109
Corcoran J / 1999 / Nerve growth factor acts via retinoic acid synthesis to stimulate neurite outgrowth 2 : 307 ~ 308
Farah MH / 2000 / Generation of neurons by transient expression of neural bHLH proteins in mammalian cells 127 : 693 ~ 702
Bonni A / 1997 / Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway 278 : 477 ~ 483
Cho JH / 2001 / Overexpression of BETA2/NeuroD induces neurite outgrowth in F11 neuroblastoma cells 77 : 103 ~ 109
Corcoran J / 1999 / Nerve growth factor acts via retinoic acid synthesis to stimulate neurite outgrowth 2 : 307 ~ 308
Farah MH / 2000 / Generation of neurons by transient expression of neural bHLH proteins in mammalian cells 127 : 693 ~ 702
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