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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 375 - 384 (10page)
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초록· 키워드
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Lysophosphatidylcholine (LPC) is a bioactive lipid generated by phospholipase A2-mediated hydro -
lysis of phosphatidylcholine. In the present study, we demonstrate that LPC stimulates phospholipase D2
(PLD2) activity in rat pheochromocytoma PC12 cells.
Serum deprivation induced cell death of PC12 cells, as demonstrated by decreased viability, DNA frag - mentation, and increased sub-G1 fraction of cell cycle. LPC treatment protected PC12 cells partially from the cell death and induced neurite outgrowth of the cells. Overexpression of PLD2 drastically en - hanced the LPC-induced inhibition of apoptosis and neuritogenesis. Pretreatment of the cells with 1-butanol, a PLD inhibitor, completely abrogated the
LPC-induced inhibition of apoptosis and neurite outgrowth in PC12 cells overexpressing PLD2. These results indicate that LPC possesses the
neurotrophic effects, such as anti-apoptosis and neurite outgrowth, through activation of PLD2.
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참고문헌 (31)
참고문헌 신청
/ / Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay : 589 ~ 601
/ / a family of proteins supporting the survival of neurons : 45 ~ 56
/ / similarity to thrombin action : 247 ~ 55
/ 1996 / Role of LPC-stimulated PLD2 activity in PC12 cells 383Goodman CS Mechanisms and molecules that control growth cone guidance 19 : 341 ~ 377
/ 1997a / Cloning and expression analysis of murine phospholipase D1 326 : 745 ~ 753
/ / a family of proteins supporting the survival of neurons : 45 ~ 56
/ / similarity to thrombin action : 247 ~ 55
/ 1996 / Role of LPC-stimulated PLD2 activity in PC12 cells 383Goodman CS Mechanisms and molecules that control growth cone guidance 19 : 341 ~ 377
/ 1997a / Cloning and expression analysis of murine phospholipase D1 326 : 745 ~ 753
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