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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 418 - 426 (9page)
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초록· 키워드
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Phospholipase D (PLD) activity is known to be related to oxidant-induced cellular signaling and membrane disturbance. Previously, an induction of PLD activity in various cell lines by X-ray irradiation was observed. In this study, we examined the effect of UVC radia-10 kJ/m2of UVC irradiation, the PLD activity was stimulated approximately 10-fold over the basal activity. This UVC-induced PLD activity was found to be dependent on the presence of extracellular calcium and was inhibited by catalase as well as amifostine - an intracellular thiol antioxidant. Pre-treatments with Ro32-0432 - a selective inhibitor of protein kinase C (PKC) - and downregulation of PKC by preincubation of phorbol 12-myristate 13-acetate significantly inhibited the UVC-induced PLD activity. UVC-stimulated PLD activity was observed only in murine PLD2 (mPLD2)-transfected Vero 76 cells and not in human PLD1 (hPLD1)-transfected cells. Tran-sient incorporation of PKC with mPLD2 and the phosphorylation of mPLD2 byα and β forms of PKC by UVC irradiation were observed. These results suggest that the UVC-stimulated PLD activity in Vero 76 cells is mediated through transient phosphor-ylation of PLD2 by the translocation of PKC to PLD2.
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참고문헌 (32)
참고문헌 신청
/ / Catalytic properties of phospholipaseD using phosphatidic acid as an activator : 585 ~ 600
/ / Identification ofphosphatidylcholine-selective and phosphatidylinositol-selectivephospholipases D in Madin-Darby canine kidney cells : 16859 ~ 65
/ / Thrombin stimulation ofhuman endothelial cell phospholipase D activity. and cyclic ade (sine3'5'-mophosphate) : 2056 ~ 67
/ 1993 / ADP-ribosylation factor, a small GTP-dependentregulatory protein, stimulates phospholipase D activity : 1137 ~ 44
/ 1996 / PhospholipaseD mediated transphospatidylation as a possible newpathway of ethanol metabolism in isolated rat pancreaticacini : 385 ~ 395
/ / Identification ofphosphatidylcholine-selective and phosphatidylinositol-selectivephospholipases D in Madin-Darby canine kidney cells : 16859 ~ 65
/ / Thrombin stimulation ofhuman endothelial cell phospholipase D activity. and cyclic ade (sine3'5'-mophosphate) : 2056 ~ 67
/ 1993 / ADP-ribosylation factor, a small GTP-dependentregulatory protein, stimulates phospholipase D activity : 1137 ~ 44
/ 1996 / PhospholipaseD mediated transphospatidylation as a possible newpathway of ethanol metabolism in isolated rat pancreaticacini : 385 ~ 395
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