지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 634 - 642 (9page)
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초록· 키워드
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In a preliminary study, we found that benzyloxycarbonyl- Val-Ala-Asp(OMe)-fluoromethylketone (zVADfmk), unlike Boc-aspartyl(OMe)-fluoromethylketone (BocD-fmk), at usual dosage could not prevent genistein- induced apoptosis of p815 mastocytoma cells.
This study was undertaken to reveal the mechanism underlying the incapability of zVAD-fmk in preventing this type of apoptosis. We observed that 14-3-3 protein level was reduced in genistein-treated cells and that BocD-fmk but not zVAD-fmk prevented the reduction of 14-3-3 protein level and the release of Bad from 14-3-3. We also demonstrated that truncated Bad to Bcl-xL interaction in genisteintreated cells was prevented by BocD-fmk but not by zVAD-fmk treatment. Our data indicate that BocDfmk, compared to zVAD-fmk, has a certain preference for inhibiting 14-3-3/Bad signalling pathway. We also elucidated that this differential efficacy of BocD-fmk and zVAD-fmk resulted from the different effect in inhibiting caspase-6 and that co-treatment of zVAD-fmk and caspase-6 specific inhibitor substantially prevented genistein-induced apoptosis.
Our data shows that caspase-6 plays a role on Bad/14-3-3 pathway in genistein-induced apoptosis of p815 cells, and that the usual dose of zVAD-fmk, in contrast to BocD-fmk, did not prevent caspase-6 acting on 14-3-3/Bad-mediated event.
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참고문헌 (22)
참고문헌 신청
/ 1995 / Fluticasone propionate:an update on preclinical and clinical experience 89 : 3 ~ 18
/ 1995 / Mast cell ontogeny and apoptosis. 4 : 227 ~ 230
/ 1997 / Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak 136 : 215 ~ 227
/ 1999 / Caspase inhibitors 6 : 1081 ~ 1086
/ 1999 / Ceramide induces caspase independent apoptosis in rat hepatocytes sensitized by inhibition of RNA synthesis 30 : 215 ~ 222
/ 1995 / Mast cell ontogeny and apoptosis. 4 : 227 ~ 230
/ 1997 / Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak 136 : 215 ~ 227
/ 1999 / Caspase inhibitors 6 : 1081 ~ 1086
/ 1999 / Ceramide induces caspase independent apoptosis in rat hepatocytes sensitized by inhibition of RNA synthesis 30 : 215 ~ 222
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