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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 461 - 476 (16page)
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초록· 키워드
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Reactive oxygen species (ROS) performs a pivotal function as a signaling mediator in receptor-mediated signaling. However, the sources of ROS in this signaling have yet to be determined, but may include lipoxygenases (LOXs) and NADPH oxidase. The stimulation of lymphoid cells with TNF-α, IL-1β, and LPS resulted in significant ROS production and NF-κB activation. Intriguingly, these responses were markedly abolished via treatment with the LOXs inhibitor nordihydroguaiaretic acid (NDGA). We further examined in vivo anti-inflammatory effects of NDGA in allergic airway inflammation. Both intraperitoneal and intravenous NDGA administration attenuated ovalbumin (OVA)-induced influx into the lungs of total leukocytes, as well as IL-4, IL-5, IL-13, and TNF-α levels.
NDGA also significantly reduced serum levels of OVA-specific IgE and suppressed OVA-induced airway hyperresponsiveness to inhaled methacholine.
The results of our histological studies and flow cytometric analyses showed that NDGA inhibits OVA-induced lung inflammation and the infiltration of CD11b+ macrophages into the lung. Collectively, our findings indicate that LOXs performs an essential function in pro-inflammatory signaling via the regulation of ROS regulation, and also that the inhibition of LOXs activity may have therapeutic potential with regard to the treatment of allergic airway inflammation.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Adler V / 1999 / Role of redox potential and reactive oxygen species in stress signalling / Oncogene 18 : 6104 ~ 11
Aggarwal BB / 2003 / Signalling pathways of the TNF superfamily: a double-edged sword / Nat Rev Immunol 3 : 745 ~ 56
Akdis CA / 2006 / Allergy and hypersensitivity: mechanisms of allergic disease / Curr Opin Immunol 18 : 718 ~ 26
Andreadis AA / 2003 / Oxidative and nitrosative events in asthma / Free Radic Biol Med 35 : 213 ~ 25
Arasaki K / 2007 / Nordihydroguaiaretic Acid affects multiple Dynein-dynactin functions in interphase and mitotic cells / Mol Pharmacol 71 : 454 ~ 60
Aggarwal BB / 2003 / Signalling pathways of the TNF superfamily: a double-edged sword / Nat Rev Immunol 3 : 745 ~ 56
Akdis CA / 2006 / Allergy and hypersensitivity: mechanisms of allergic disease / Curr Opin Immunol 18 : 718 ~ 26
Andreadis AA / 2003 / Oxidative and nitrosative events in asthma / Free Radic Biol Med 35 : 213 ~ 25
Arasaki K / 2007 / Nordihydroguaiaretic Acid affects multiple Dynein-dynactin functions in interphase and mitotic cells / Mol Pharmacol 71 : 454 ~ 60
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